In: PLoS pathogens, 2015, vol. 11, no. 10, p. e1005164
Candida spp. can cause severe and chronic mucocutaneous and systemic infections in immunocompromised individuals. Protection from mucocutaneous candidiasis depends on T helper cells, in particular those secreting IL-17. The events regulating T cell activation and differentiation toward effector fates in response to fungal invasion in different tissues are poorly understood. Here we generated...
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In: Frontiers in immunology, 2014, vol. 5, p. 259
Thymocytes and thymic epithelial cells (TECs) cross-talk is essential to support T cell development and preserve thymic architecture and maturation of TECs and Foxp3+ natural regulatory T cells. Accordingly, disruption of thymic lymphostromal cross-talk may have major implications on the thymic mechanisms that govern T cell tolerance. Several genetic defects have been described in humans that...
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In: Plos pathogens, 2011, vol. 7, no. 9, p. e1002231
Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that TaxHTLV-1 interferes with ß- selection, an important checkpoint of early thymopoiesis, indicating that human T-cell leukemia virus type 1 (HTLV-1) infection has the potential to perturb thymic human αβ T-cell development. To...
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In: Journal of experimental medicine, 2010, vol. 207, no. 3, p. 565-577
Interleukin (IL)-10 produced by regulatory T cell subsets is important for the prevention of autoimmunity and immunopathology, but little is known about the phenotype and function of IL-10–producing memory T cells. Human CD4+CCR6+ memory T cells contained comparable numbers of IL-17– and IL-10–producing cells, and CCR6 was induced under both Th17-promoting conditions and upon tolerogenic...
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In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 10, p. 2254-2265
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In: Journal of Mammary Gland Biology and Neoplasia, 2006, vol. 11, no. 3-4, p. 239-248
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In: Cellular and Molecular Life Sciences, 2007, vol. 64, no. 21, p. 2746-2762
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In: Cellular and Molecular Life Sciences, 2008, vol. 65, no. 6, p. 1005-1005
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In: Cancer Immunology, Immunotherapy, 2007, vol. 56, no. 11, p. 1795-1805
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In: Stem Cell Reviews, 2007, vol. 3, no. 2, p. 147-156
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