In: Gut microbes, 2021, vol. 13, no. 1, p. 20
Intestinal microbiota regulates multiple host metabolic and immunological processes. Consequently, any difference in its qualitative and quantitative composition is susceptible to exert significant effects, in particular along the gut-liver axis. Indeed, recent findings suggest that such changes modulate the severity and the evolution of a wide spectrum of hepatobiliary disorders. However, the...
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In: Toxicological Sciences, 2017, vol. 159, no. 1, p. 266-276
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In: European Journal of Wildlife Research, 2015, vol. 61, no. 1, p. 171-176
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In: European Journal of Pediatrics, 2015, vol. 174, no. 2, p. 151-167
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In: Advances in Nutrition, 2017, vol. 8, no. 6, p. 839-849
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In: Cell reports, 2017, vol. 18, no. 11, p. 2566-2575
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of...
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In: Scientific reports, 2019, vol. 9, p. 9315
The secretory immunoglobulin A (SIgA) in mammalian gut protects the organism from infections and contributes to host physiology by shaping microbiota composition. The mechanisms regulating the adaptive SIgA response towards gut microbes are poorly defined. Deletion of P2rx7, encoding for the ATP-gated ionotropic P2X7 receptor, leads to T follicular helper (Tfh) cells expansion in the Peyer’s...
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In: Current Microbiology, 2014, vol. 68, no. 4, p. 419-427
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In: The journal of experimental medicine, 2016, vol. 213, no. 3, p. 355-375
Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated. Here, we show that Rag2R229Q knock-in mice developed an inflammatory bowel disease affecting...
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In: European Journal of Nutrition, 2006, vol. 45, no. 8, p. 445-453
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