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Università della Svizzera italiana

Phase angle is associated with length of hospital stay, readmissions, mortality, and falls in patients hospitalized in internal-medicine wards : a retrospective cohort study

Del Giorno, Rosaria ; Quarenghi, Massimo ; Stefanelli, Kevyn ; Rigamonti, Alice ; Stanglini, Carlotta ; De Vecchi, Valentina ; Gabutti, Luca

In: Nutrition, 2021, vol. 85, no. May, p. 7 p

The aim of this study was to investigate the predictive value of bioimpedance phase angle (PA) on selected clinical outcomes in patients hospitalized in internal-medicine wards. This was a retrospective observational study of 168 patients admitted to the internalmedicine service (52.9% women, 47.1% men), with a mean (± SD) age of 73.9 ± 15.9 y. Anthropometric examination, laboratory tests,...

Université de Fribourg

Effects of statins to reduce all-cause mortality in heart failure patients: findings from the epical2 cohort study

Al‑Gobari, Muaamar ; Agrinier, Nelly ; Soudant, Marc ; Burnand, Bernard ; Thilly, Nathalie

In: American Journal of Cardiovascular Drugs, 2019, vol. 19, no. 5, p. 497–508

Introduction: The addition of statins to standard care in heart failure (HF) patients remains controversial in clinical practice. Large-scale clinical trials failed to show mortality benefits, but uncertainty persists in real-world settings.Objective: We evaluated whether the prescription of statins at hospital discharge is associated with a reduction in all-cause mortality at up to 1 year of...

Università della Svizzera italiana

SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination

Daddacha, Waaqo ; Koyen, Allyson E. ; Bastien, Amanda J. ; Head,Pamela Sara E. ; Dhere, Vishal R. ; Nabeta, Geraldine N. ; Connolly, Erin C. ; Werner, Erica ; Madden, Matthew Z. ; Daly, Michele B. ; Minten, Elizabeth V. ; Whelan, Donna R. ; Schlafstein, Ashley J. ; Zhang, Hui ; Anand, Roopesh ; Doronio, Christine ; Withers, Allison E. ; Shepard, Caitlin ; Sundaram, Ranjini K. ; Deng, Xingming ; Dynan, William S. ; Wang, Ya ; Bindra, Ranjit S. ; Cejka, Petr ; Rothenberg, Eli ; Doetsch, Paul W. ; Kim, Baek ; Yu, David S.

In: Cell reports, 2017, vol. 20, no. 8, p. 1921-1935

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV- 1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate...

Consortium of Swiss Academic Libraries

p53 and the CNS : Tumors and developmental abnormalities

Fulci, Giulia ; Van Meir, Erwin

In: Molecular Neurobiology, 1999, vol. 19, no. 1, p. 61-77