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Università della Svizzera italiana

Glomerular macrophages in human auto- and allo-immune nephritis

Moll, Solange ; Angeletti, Andrea ; Scapozza, Leonardo ; Cavalli, Andrea ; Ghiggeri, Gian Marco ; Prunotto, Marco

In: Cells, 2021, vol. 10, no. 3, p. 19 p

Macrophages are involved in tissue homeostasis. They participate in inflammatory episodes and are involved in tissue repair. Macrophages are characterized by a phenotypic heterogeneity and a profound cell plasticity. In the kidney, and more particularly within glomeruli, macrophages are thought to play a maintenance role that is potentially critical for preserving a normal glomerular structure....

Université de Fribourg

An inflamed human alveolar model for testing the efficiency of anti-inflammatory drugs in vitro

Drasler, Barbara ; Karakocak, Bedia Begum ; Tankus, Esma Bahar ; Barosova, Hana ; Abe, Jun ; Sousa de Almeida, Mauro ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Frontiers in Bioengineering and Biotechnology, 2020, vol. 8, p. -

A large number of prevalent lung diseases is associated with tissue inflammation. Clinically, corticosteroid therapies are applied systemically or via inhalation for the treatment of lung inflammation, and a number of novel therapies are being developed that require preclinical testing. In alveoli, macrophages and dendritic cells play a key role in initiating and diminishing pro-inflammatory...

Università della Svizzera italiana

LPS nephropathy in mice is ameliorated by IL-2 independently of regulatory T cells activity

Bertelli, Roberta ; Di Donato, Armando ; Cioni, Michela ; Grassi, Fabio ; Ikehata, Masami ; Bonanni, Alice ; Rastaldi, Maria Pia ; Ghiggeri, Gian Marco

In: Plos one, 2014, vol. 9, no. 10, p. e111285

Immunosuppressive regulatory T cells (Tregs) have been hypothesized to exert a protective role in animal models of spontaneous (Buffalo/Mna) and/or drug induced (Adriamycin) nephrotic syndrome. In this study, we thought to define whether Tregs can modify the outcome of LPS nephropathy utilizing IL-2 as inducer of tissue and circulating Tregs. LPS (12 mg/Kg) was given as single shot in C57BL/6,...

Consortium of Swiss Academic Libraries

Five-year outcome in immune-mediated scleritis

Bernauer, Wolfgang ; Pleisch, Beat ; Brunner, Matthias

In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2014, vol. 252, no. 9, p. 1477-1481

Consortium of Swiss Academic Libraries

Monogenic forms of hypertension

Simonetti, Giacomo ; Mohaupt, Markus ; Bianchetti, Mario

In: European Journal of Pediatrics, 2012, vol. 171, no. 10, p. 1433-1439