In: Oncogene, 2021, vol. 40, no. 7, p. 1205–1216
Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully i mplemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increase of prostate cancers that de-differentiate...
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In: AoB PLANTS, 2016, vol. 8, no. 1, p. -
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In: Transformation Groups, 2015, vol. 20, no. 1, p. 1-20
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In: Virchows Archiv, 2015, vol. 466, no. 5, p. 485-493
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In: Human Molecular Genetics, ///-
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In: Earth, Moon, and Planets, 2015, vol. 116, no. 3, p. 141-157
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Mémoire de bachelor : Haute école de santé Genève, 2020.
L'objectif de cette revue de littérature, est d'identifier les interventions infirmières permettant de soutenir les hommes atteints du cancer de la prostate faisant face à de l'incertitude et de décrire leurs vécus face à celle-ci. Les bases de données Pubmed et Cinhal on été consultées entre le 3 décembre 2019 et le 14 février 2020. Parmi les huit études retenues, les devis...
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In: Blood, 2020, vol. 135, no. 21, p. 1859–1869
Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients...
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In: Cell Systems, 2020, vol. 11, no. 6, p. 557-572.e5
Temporal interference (TI) is a non-invasive neurostimulation technique that utilizes high-frequency external electric fields to stimulate deep neuronal structures without affecting superficial, off-target structures. TI represents a potential breakthrough for treating conditions, such as Parkinson’s disease and chronic pain. However, early clinical work on TI stimulation was met with mixed...
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In: Shock, 2020, vol. 53, no. 5, p. 653–665
Objective: Activation of the constitutive nuclear and mitochondrial enzyme poly (ADP- ribose) polymerase (PARP) has been implicated in the pathogenesis of cell dysfunction, inflammation, and organ failure in various forms of critical illness. The objective of our study was to evaluate the efficacy and safety of the clinically approved PARP inhibitor olaparib in an experimental model of...
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