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Université de Fribourg

Colistin resistance in Parisian inpatient faecal Escherichia coli as the result of two distinct evolutionary pathways

Bourrel, Anne Sophie ; Poirel, Laurent ; Royer, Guilhem ; Darty, Mélanie ; Vuillemin, Xavier ; Kieffer, Nicolas ; Clermont, Olivier ; Denamur, Erick ; Nordmann, Patrice ; Decousser, Jean-Winoc ; The IAME Resistance Group

In: Journal of Antimicrobial Chemotherapy, 2019, vol. 74, no. 6, p. 1521–1530

Beyond plasmid-encoded resistance (mcr genes) prevalence in strain collections, large epidemiological studies to estimate the human burden of colistin-resistant Escherichia coli gut carriage are lacking.Objectives: To evaluate the prevalence of colistin-resistant E. coli carriage in inpatients and decipher the molecular support of resistance and the genetic background of the strains.Methods:...

Université de Fribourg

Integrase-mediated recombination of the bel-1 gene cassette encoding the extended-spectrum β-lactamase BEL-1

Bouheraoua, Nacim ; Poirel, Laurent ; Bourreau, Baptiste ; Bonnin, Rémy ; Laroche, Laurent ; Naas, Thierry ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2018, p. AAC.00030-18

Integrons are genetic elements that can acquire and rearrange gene cassettes. The blaBEL-1 gene encodes an extended-spectrum β-lactamase, BEL-1, that is present at second position of the variable region of class 1 integrons identified in Pseudomonas aeruginosa. The mobility of the bel-1 gene cassette was analyzed in physiological conditions and with the integrase gene being overexpressed....

Consortium of Swiss Academic Libraries

An XMM—Newton observation of the young open cluster NGC 2547: coronal activity at 30 Myr

Jeffries, R. D. ; Evans, P. A. ; Pye, J. P. ; Briggs, K. R.

In: Monthly Notices of the Royal Astronomical Society, 2006, vol. 367, no. 2, p. 781-800