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Exon–Intron differential analysis reveals the role of competing endogenous RNAs in post-transcriptional regulation of translation

Munz, Nicolas ; Cascione, Luciano ; Parmigiani, Luca ; Tarantelli, Chiara ; Rinaldi, Andrea ; Cmiljanovic, Natasa ; Cmiljanovic, Vladimir ; Giugno, Rosalba ; Bertoni, Francesco ; Napoli, Sara

In: Non-coding RNA, 2021, vol. 7, no. 2, p. 13

Stressful conditions induce the cell to save energy and activate a rescue program modulated by mammalian target of rapamycin (mTOR). Along with transcriptional and translational regulation, the cell relies also on post-transcriptional modulation to quickly adapt the translation of essential proteins. MicroRNAs play an important role in the regulation of protein translation, and their...

IL-1 Antagonism in Men With Metabolic Syndrome and Low Testosterone: A Randomized Clinical Trial

Ebrahimi, Fahim ; Urwyler, Sandrine A. ; Straumann, Sven ; Doerpfeld, Simone ; Bernasconi, Luca ; Neyer, Peter ; Schuetz, Philipp ; Mueller, Beat ; Donath, Marc Y. ; Christ-Crain, Mirjam

In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 9, p. 3466-3476

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups

Weller, Michael ; Weber, Ruthild ; Willscher, Edith ; Riehmer, Vera ; Hentschel, Bettina ; Kreuz, Markus ; Felsberg, Jörg ; Beyer, Ulrike ; Löffler-Wirth, Henry ; Kaulich, Kerstin ; Steinbach, Joachim ; Hartmann, Christian ; Gramatzki, Dorothee ; Schramm, Johannes ; Westphal, Manfred ; Schackert, Gabriele ; Simon, Matthias ; Martens, Tobias ; Boström, Jan ; Hagel, Christian ; Sabel, Michael ; Krex, Dietmar ; Tonn, Jörg ; Wick, Wolfgang ; Noell, Susan ; Schlegel, Uwe ; Radlwimmer, Bernhard ; Pietsch, Torsten ; Loeffler, Markus ; von Deimling, Andreas ; Binder, Hans ; Reifenberger, Guido

In: Acta Neuropathologica, 2015, vol. 129, no. 5, p. 679-693

Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics

McKinnon, Brett D. ; Kocbek, Vida ; Nirgianakis, Kostantinos ; Bersinger, Nick A. ; Mueller, Michael D.

In: Human Reproduction Update, 2016, vol. 22, no. 3, p. 382-403

Malignant optic glioma - the spectrum of disease in a case series

Traber, G L.

In: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie, ///-

mTOR in health and in sickness

Liko, Dritan ; Hall, Michael

In: Journal of Molecular Medicine, 2015, vol. 93, no. 10, p. 1061-1073

Was ist neu in der Pathologie neuroendokriner Tumoren des Pankreas? = What is new in the pathology of pancreatic neuroendocrine tumors?

Komminoth, P. ; Perren, A.

In: Der Pathologe, 2015, vol. 36, no. 3, p. 220-228

Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy

Shende, Pankaj ; Xu, Lifen ; Morandi, Christian ; Pentassuglia, Laura ; Heim, Philippe ; Lebboukh, Sonia ; Berthonneche, Corinne ; Pedrazzini, Thierry ; Kaufmann, Beat A. ; Hall, Michael N. ; Rüegg, Markus A. ; Brink, Marijke

In: Cardiovascular Research, 2016, vol. 109, no. 1, p. 103-114

Interleukin-1 Antagonism Decreases Cortisol Levels in Obese Individuals

Urwyler, Sandrine Andrea ; Schuetz, Philipp ; Ebrahimi, Fahim ; Donath, Marc Y. ; Christ-Crain, Mirjam

In: The Journal of Clinical Endocrinology & Metabolism, 2017, vol. 102, no. 5, p. 1712-1718

The novel TORC1/2 kinase inhibitor PQR620 has anti-tumor activity in lymphomas as a single agent and in combination with venetoclax

Tarantelli, Chiara ; Gaudio, Eugenio ; Hillmann, Petra ; Spriano, Filippo ; Sartori, Giulio ; Aresu, Luca ; Cascione, Luciano ; Rageot, Denise ; Kwee, Ivo ; Beaufils, Florent ; Zucca, Emanuele ; Stathis, Anastasios ; Wymann, Matthias P. ; Cmiljanovic, Vladimir ; Fabbro, Doriano ; Bertoni, Francesco

In: Cancers, 2019, vol. 11, no. 6, p. 775

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling cascade is an important therapeutic target for lymphomas. Rapamycin-derivates as allosteric mTOR complex 1 (TORC1) inhibitors have shown moderate preclinical and clinical anti-lymphoma activity. Here, we assessed the anti-tumor activity of PQR620, a novel brain penetrant dual TORC1/2 inhibitor, in 56...