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ENaC activity in collecting ducts modulates NCC in cirrhotic mice

Mordasini, David ; Loffing-Cueni, Dominique ; Loffing, Johannes ; Beatrice, Rohrbach ; Maillard, Marc ; Hummler, Edith ; Burnier, Michel ; Escher, Geneviève ; Vogt, Bruno

In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 12, p. 2529-2539

γδ T cells kill Plasmodium falciparum in a granzyme- and granulysin-dependent mechanism during the late blood stage

Hernández-Castañeda, Maria Andrea ; Happ, Katharina ; Cattalani, Filippo ; Wallimann, Alexandra ; Blanchard, Marianne ; Fellay, Isabelle ; Scolari, Brigitte ; Lannes, Nils ; Mbagwu, Smart Ikechukwu ; Fellay, Benoît ; Filgueira, Luis ; Mantel, Pierre-Yves ; Walch, Michael

In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809

Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...

Influenza vaccination induces NK-cell-mediated type-II IFN response that regulates humoral immunity in an IL-6-dependent manner

Farsakoglu, Yagmur ; Palomino-Segura, Miguel ; Latino, Irene ; Zanaga, Silvia ; Chatziandreou, Nikolaos ; Pizzagalli, Diego Ulisse ; Rinaldi, Andrea ; Bolis, Marco ; Sallusto, Federica ; Stein, Jens V. ; Gonzalez, Santiago F.

In: Cell reports, 2019, vol. 26, no. 9, p. 2307-2315.e5

The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of...

Macrophage death following influenza vaccination initiates the inflammatory response that promotes dendritic cell function in the draining lymph node

Chatziandreou, Nikolaos ; Farsakoglu, Yagmur ; Palomino-Segura, Miguel ; D’Antuono, Rocco ; Pizzagalli, Diego Ulisse ; Sallusto, Federica ; Lukacs-Kornek, Veronika ; Uguccioni, Mariagrazia ; Corti, Davide ; Turley, Shannon J. ; Lanzavecchia, Antonio ; Carroll, Michael C. ; Gonzalez, Santiago F.

In: Cell reports, 2017, vol. 18, no. 10, p. 2427-2440

The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine. Following vaccination, LNMs undergo inflammasome-independent necrosis-like death that is reliant on MyD88 and Toll-like receptor 7 (TLR7)...

Rag defects and thymic stroma : lessons from animal models

Marrella, Veronica ; Poliani, Pietro Luigi ; Notarangelo, Luigi Daniele ; Grassi, Fabio ; Villa, Anna

In: Frontiers in immunology, 2014, vol. 5, p. 259

Thymocytes and thymic epithelial cells (TECs) cross-talk is essential to support T cell development and preserve thymic architecture and maturation of TECs and Foxp3+ natural regulatory T cells. Accordingly, disruption of thymic lymphostromal cross-talk may have major implications on the thymic mechanisms that govern T cell tolerance. Several genetic defects have been described in humans that...

The adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity

Valaperti, Alan ; Nishii, Mototsugu ; Liu, Youan ; Yang, Howard ; Naito, Kotaro ; Liu, Peter ; Eriksson, Urs

In: Basic Research in Cardiology, 2014, vol. 109, no. 3, p. 1-14

Postmortem diagnosis of hypothermia

Palmiere, Cristian ; Teresiński, Grzegorz ; Hejna, Petr

In: International Journal of Legal Medicine, 2014, vol. 128, no. 4, p. 607-614

Influence of natural killer cells and perforin-mediated cytolysis on the development of chemically induced lung cancer in A/J mice

Frese-Schaper, Manuela ; Keil, Andreas ; Yagita, Hideo ; Steiner, Selina ; Falk, Werner ; Schmid, Ralph ; Frese, Steffen

In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 6, p. 571-580

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

Lan, Qiang ; Peyvandi, Sanam ; Duffey, Nathalie ; Huang, Yu-Ting ; Barras, David ; Held, Werner ; Richard, François ; Delorenzi, Mauro ; Sotiriou, Christos ; Desmedt, Christine ; Lorusso, Girieca ; Rüegg, Curzio

In: Oncogene, 2019, vol. 38, no. 15, p. 2814–2829

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental...

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Vogl, Claus ; Flatt, Thomas ; Fuhrmann, Bernd ; Hofmann, Elisabeth ; Wallner, Barbara ; Stiefvater, Rita ; Kovarik, Pavel ; Strobl, Birgit ; Müller, Mathias

In: BMC Genomics, 2010, vol. 11, no. 199, p. 1-19

Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment....