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Université de Fribourg

Bacterial oxidases of the cytochrome bd family : redox enzymes of unique structure, function, and utility as drug targets

Borisov, Vitaliy B. ; Siletsky, Sergey A. ; Paiardini, Alessandro ; Hoogewijs, David ; Forte, Elena ; Giuffrè, Alessandro ; Poole, Robert K.

In: Antioxidants & Redox Signaling, 2021, vol. 34, no. 16, p. 1280-1318

Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many ...

Université de Fribourg

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions

Marques, Filipe ; Thapliyal, Saurabh ; Javer, Avelino ; Shrestha, Priyanka ; Brown, André E. X. ; Glauser, Dominique A.

In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102

Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...

Université de Fribourg

Predicting abundances of invasive ragweed across Europe using a “top-down” approach

Skjøth, Carsten Ambelas ; Sun, Yan ; Karrer, Gerhard ; Sikoparija, Branko ; Smith, Matt ; Schaffner, Urs ; Müller-Schärer, Heinz

In: Science of The Total Environment, 2019, vol. 686, p. 212–222

Common ragweed (Ambrosia artemisiifolia L.) is a widely distributed and harmful invasive plant that is an important source of highly allergenic pollen grains and a prominent crop weed. As a result, ragweed causes huge costs to both human health and agriculture in affected areas. Efficient mitigation requires accurate mapping of ragweed densities that, until now, has not been achieved...

Università della Svizzera italiana

Influenza hemagglutinin membrane anchor

Benton, Donald J. ; Nans, Andrea ; Calder, Lesley J. ; Turner, Jack ; Neu, Ursula ; Lin, Yi Pu ; Ketelaars, Esther ; Kallewaard, Nicole L. ; Corti, Davide ; Lanzavecchia, Antonio ; Gamblin, Steven J. ; Rosenthal, Peter B. ; Skehel, John J.

In: Proceedings of the national academy of sciences of the United States of America, 2018, vol. 115, no. 40, p. 10112-10117

Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the “membrane anchor” portion of the...

Université de Fribourg

Remote sensing of cropping practice in Northern Italy using time-series from Sentinel-2

Ottosen, Thor-Bjørn ; Lommen, Suzanne T.E. ; Skjøth, Carsten Ambelas

In: Computers and Electronics in Agriculture, 2019, vol. 157, p. 232–238

Maps of cropping practice, including the level of weed infestation, are useful planning tools e.g. for the assessment of the environmental impact of the crops, and Northern Italy is an important example due to the large and diverse agricultural production and the high weed infestation. Sentinel-2A is a new satellite with a high spatial and temporal resolution which potentially allows the...

Université de Fribourg

Evolution of longevity improves immunity in Drosophila

Fabian, Daniel K. ; Garschall, Kathrin ; Klepsatel, Peter ; Santos-Matos, Gonçalo ; Sucena, Élio ; Kapun, Martin ; Lemaitre, Bruno ; Schlötterer, Christian ; Arking, Robert ; Flatt, Thomas

In: Evolution Letters, 2018, vol. 2, no. 6, p. 567–579

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin signaling as a major regulator of longevity, yet whether standing variation in this pathway underlies microevolutionary changes in...

Consortium of Swiss Academic Libraries

Multimodality cardiac imaging

Gaemperli, Oliver ; Kaufmann, Philipp

In: Journal of Nuclear Cardiology, 2010, vol. 17, no. 1, p. 4-7