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The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity

Hess, Christian ; Neri, Dario

In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 5, p. 635-644

Anti-tumor necrosis factor drug survival in axial spondyloarthritis is independent of the classification criteria

Zufferey, Pascal ; Ghosn, Jacqueline ; Becce, Fabio ; Ciurea, Adrian ; Aubry-Rozier, Bérengère ; Finckh, Axel ; So, Alexander

In: Rheumatology International, 2015, vol. 35, no. 2, p. 295-302

Innate immune cells and their contribution to T-cell-based immunotherapy

Ginefra, Pierpaolo ; Lorusso, Girieca ; Vannini, Nicola

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 12, p. 4441

In recent years, immunotherapy has become the most promising therapy for a variety of cancer types. The development of immune checkpoint blockade (ICB) therapies, the adoptive transfer of tumor-specific T cells (adoptive cell therapy (ACT)) or the generation of T cells engineered with chimeric antigen receptors (CAR) have been successfully applied to elicit durable immunological responses in...

Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo

Rota, Giorgia ; Niogret, Charlène ; Dang, Anh Thu ; Ramon Barros, Cristina ; Fonta, Nicolas Pierre ; Alfei, Francesca ; Morgado, Leonor ; Zehn, Dietmar ; Birchmeier, Walter ; Vivier, Eric ; Guarda, Greta

In: Cell reports, 2018, vol. 23, no. 1, p. 39-49

In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell- specific Shp-2-deficient mice. These...

Immunological aspects of atherosclerosis

Garrido-Urbani, S. ; Meguenani, M. ; Montecucco, F. ; Imhof, B.

In: Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91

Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy

Pretto, Francesca ; Elia, Giuliano ; Castioni, Nadia ; Neri, Dario

In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 9, p. 901-910

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

Muenst, S. ; Schaerli, A. ; Gao, F. ; Däster, S. ; Trella, E. ; Droeser, R. ; Muraro, M. ; Zajac, P. ; Zanetti, R. ; Gillanders, W. ; Weber, W. ; Soysal, S.

In: Breast Cancer Research and Treatment, 2014, vol. 146, no. 1, p. 15-24

Nicotinic Cholinergic Signaling in Adipose Tissue and Pancreatic Islets Biology: Revisited Function and Therapeutic Perspectives

Somm, Emmanuel

In: Archivum Immunologiae et Therapiae Experimentalis, 2014, vol. 62, no. 2, p. 87-101

Influence of natural killer cells and perforin-mediated cytolysis on the development of chemically induced lung cancer in A/J mice

Frese-Schaper, Manuela ; Keil, Andreas ; Yagita, Hideo ; Steiner, Selina ; Falk, Werner ; Schmid, Ralph ; Frese, Steffen

In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 6, p. 571-580

Nuclear localization of mouse fibroblast growth factor 2 requires N-terminal and C-terminal sequences

Foletti, A. ; Vuadens, F. ; Beermann, F.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 10, p. 2254-2265