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Université de Fribourg

Role of the thalamus in basal forebrain regulation of neural activity in the primary auditory cortex

Azimi, Hamid ; Klaassen, Arndt-Lukas ; Thomas, Kevin ; Harvey, Michael A. ; Rainer, Gregor

In: Cerebral Cortex, 2020, vol. 30, no. 8, p. 4481–4495

Many studies have implicated the basal forebrain (BF) as a potent regulator of sensory encoding even at the earliest stages of or cortical processing. The source of this regulation involves the well-documented corticopetal cholinergic projections from BF to primary cortical areas. However, the BF also projects to subcortical structures, including the thalamic reticular nucleus (TRN), which...

Université de Fribourg

Stimulus reward value interacts with training-induced plasticity in inhibitory control

Pretto, Michael De ; Hartmann, Lea ; Garcia-Burgos, David ; Sallard, Etienne ; Spierer, Lucas

In: Neuroscience, 2019, vol. 421, p. 82–94

Training inhibitory control, the ability to suppress motor or cognitive processes, not only enhances inhibition processes, but also reduces the perceived value and behaviors toward the stimuli associated with the inhibition goals during the practice. While these findings suggest that inhibitory control training interacts with the aversive and reward systems, the underlying spatio-temporal...

Université de Fribourg

Practice-induced functional plasticity in inhibitory control interacts with aging

Hartmann, Lea ; Wachtl, Laura ; Lucia, Marzia de ; Spierer, Lucas

In: Brain and Cognition, 2019, vol. 132, p. 22–32

Inhibitory control deficits represent a key aspect of the cognitive declines associated with aging. Practicing inhibitory control has thus been advanced as a potential approach to compensate for age-induced neurocognitive impairments. Yet, the functional brain changes associated with practicing inhibitory control tasks in older adults and whether they differ from those observed in young...