In: Cancer treatment reviews, 2020, vol. 90, p. 11
The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...
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In: Nutrients, 2020, vol. 12, no. 11, p. 10 p
Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid–base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the...
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In: The American Journal of Clinical Nutrition, 2018, vol. 108, no. 1, p. 101-107
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In: Cancers, 2020, vol. 12, no. 10, p. 23 p
Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB- 157 and MDA-MB-157) endowed with ATRA-sensitivity are characterized by genetic aberrations of the NOTCH1-gene,...
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In: European Journal of Nuclear Medicine and Molecular Imaging, 2014, vol. 41, no. 3, p. 476-485
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In: The journal of experimental medicine, 2016, vol. 213, no. 3, p. 355-375
Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated. Here, we show that Rag2R229Q knock-in mice developed an inflammatory bowel disease affecting...
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In: Virchows Archiv, 2013, vol. 462, no. 6, p. 609-617
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In: Cancer Causes & Control, 2011, vol. 22, no. 10, p. 1375-1382
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In: European Journal of Nuclear Medicine and Molecular Imaging, 2006, vol. 33, no. 9, p. 1007-1016
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In: Cancer Causes & Control, 2011, vol. 22, no. 1, p. 109-114
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