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Cobicistat versus ritonavir boosting and differences in the drug-drug interaction profiles with co-medications

Marzolini, Catia ; Gibbons, Sara ; Khoo, Saye ; Back, David

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 7, p. 1755-1758

Darunavir concentrations in CSF of HIV-infected individuals when boosted with cobicistat versus ritonavir

Bartels, Hanni ; Decosterd, Laurent ; Battegay, Manuel ; Marzolini, Catia

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 9, p. 2574-2577

Live Virus Vaccines in Transplantation: Friend or Foe?

Verolet, Charlotte ; Posfay-Barbe, Klara

In: Current Infectious Disease Reports, 2015, vol. 17, no. 4, p. 1-11

Comparative Genomics of Community-Associated Methicillin-Resistant Staphylococcus aureus Shows the Emergence of Clone ST8-USA300 in Geneva, Switzerland

Von Dach, Elodie ; Diene, Seydina M. ; Fankhauser, Carolina ; Schrenzel, Jacques ; Harbarth, Stephan ; François, Patrice

In: The Journal of Infectious Diseases, 2016, vol. 213, no. 9, p. 1370-1379

Reply to Planet et al

François, Patrice ; von Dach, Elodie ; Diene, Seydina M. ; Harbarth, Stephan ; Schrenzel, Jacques

In: The Journal of Infectious Diseases, 2016, vol. 214, no. 10, p. 1610-1611

The Swiss Transplant Cohort Study: Lessons from the First 6Years

Berger, Christoph ; Bochud, Pierre-Yves ; Boggian, Katja ; Cusini, Alexia ; Egli, Adrian ; Garzoni, Christian ; Hirsch, Hans ; Hoffmann, Matthias ; Khanna, Nina ; Manuel, Oriol ; Meylan, Pascal ; Nadal, David ; van Delden, Christian ; Weisser, Maja ; Mueller, Nicolas

In: Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5

NGS-based S. aureus typing and outbreak analysis in clinical microbiology laboratories : Lessons learned from a Swiss-wide proficiency test

Dylus, David ; Pillonel, Trestan ; Opota, Onya ; Wüthrich, Daniel ; Seth-Smith, Helena M. B. ; Egli, Adrian ; Leo, Stefano ; Lazarevic, Vladimir ; Schrenzel, Jacques ; Laurent, Sacha ; Bertelli, Claire ; Blanc, Dominique S. ; Neuenschwander, Stefan ; Ramette, Alban ; Falquet, Laurent ; Imkamp, Frank ; Keller, Peter M. ; Kahles, Andre ; Oberhaensli, Simone ; Barbié, Valérie ; Dessimoz, Christophe ; Greub, Gilbert ; Lebrand, Aitana

In: Frontiers in Microbiology, 2020, vol. 11, p. 591093

Whole genome sequencing (WGS) enables high resolution typing of bacteria up to the single nucleotide polymorphism (SNP) level. WGS is used in clinical microbiology laboratories for infection control, molecular surveillance and outbreak analyses. Given the large palette of WGS reagents and bioinformatics tools, the Swiss clinical bacteriology community decided to conduct a ring trial (RT) to...

Swiss consensus recommendations on urinary tract infections in children

Buettcher, Michael ; Trueck, Johannes ; Niederer-Loher, Anita ; Heininger, Ulrich ; Agyeman, Philipp ; Asner, Sandra ; Berger, Christoph ; Bielicki, Julia ; Kahlert, Christian ; Kottanattu, Lisa ; Meyer Sauteur, Patrick M. ; Paioni, Paolo ; Posfay-Barbe, Klara ; Relly, Christa ; Ritz, Nicole ; Zimmermann, Petra ; Zucol, Franziska ; Gobet, Rita ; Shavit, Sandra ; Rudin, Christoph ; Laube, Guido ; von Vigier, Rodo ; Neuhaus, Thomas J.

In: European Journal of Pediatrics, 2020, p. -

The kidneys and the urinary tract are a common source of infection in children of all ages, especially infants and young children. The main risk factors for sequelae after urinary tract infections (UTI) are congenital anomalies of the kidney and urinary tract (CAKUT) and bladder-bowel dysfunction. UTI should be considered in every child with fever without a source. The differentiation between...

Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

Volery, Maryse ; Scherz, Valentin ; Jakob, William ; Bandeira, Diane ; Deggim-Messmer, Vanessa ; Lauber-Biason, Anna ; Wildhaber, Johannes ; Falquet, Laurent ; Curtis, Nigel ; Zimmermann, Petra

In: BMJ Open, 2020, vol. 10, no. 6, p. e036275

Introduction: There is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether...

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

Stolp, Bettina ; Thelen, Flavian ; Ficht, Xenia ; Altenburger, Lukas M. ; Ruef, Nora ; Inavalli, V. V. G. Krishna ; Germann, Philipp ; Page, Nicolas ; Moalli, Federica ; Raimondi, Andrea ; Keyser, Kirsten A. ; Jafari, S. Morteza Seyed ; Barone, Francesca ; Dettmer, Matthias S. ; Merkler, Doron ; Iannacone, Matteo ; Sharpe, James ; Schlapbach, Christoph ; Fackler, Oliver T. ; Nägerl, U. Valentin ; Stein, Jens V.

In: Science Immunology, 2020, vol. 5, no. 46, p. eaaz4371

It is well established that tissue macrophages and tissue-resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for homeostatic organ surveillance after clearance of infections is poorly understood. Here, we used intravital imaging to show that TRM dynamically...