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Università della Svizzera italiana

Artificial intelligence in thyroid field : a comprehensive review

Bini, Fabiano ; Pica, Andrada ; Azzimonti, Laura ; Giusti, Alessandro ; Ruinelli, Lorenzo ; Marinozzi, Franco ; Trimboli, Pierpaolo

In: Cancers, 2021, vol. 13, no. 19, p. 18

Artificial intelligence (AI) uses mathematical algorithms to perform tasks that require human cognitive abilities. AI-based methodologies, e.g., machine learning and deep learning, as well as the recently developed research field of radiomics have noticeable potential to transform medical diagnostics. AI-based techniques applied to medical imaging allow to detect biological abnormalities, to...

Università della Svizzera italiana

Fibrin sealants and axillary lymphatic morbidity : a systematic review and meta-analysis of 23 clinical randomized trials

Gasparri, Maria Luisa ; Kuehn, Thorsten ; Ruscito, Ilary ; Zuber, Veronica ; Di Micco, Rosa ; Galiano, Ilaria ; Navarro Quinones, Siobana C. ; Santurro, Letizia ; Di Vittorio, Francesca ; Meani, Francesco ; Bassi, Valerio ; Ditsch, Nina ; Mueller, Michael D. ; Bellati, Filippo ; Caserta, Donatella ; Papadia, Andrea ; Gentilini, Oreste D.

In: Cancers, 2021, vol. 13, no. 9, p. 15

Axillary dissection is a highly mobile procedure with severe lymphatic consequences. The off-label application of fibrin sealants in the axilla, with the sole aim to eliminate dead space and to provoke sealing of the disrupted lymphatic vessels at the end of axillary dissection, is an experimental procedure to reduce lymphatic morbidity. The aim of our systematic review and meta-analysis is to ...

Università della Svizzera italiana

The ultrasound risk stratification systems for thyroid nodule have been evaluated against papillary carcinoma : a meta-analysis

Trimboli, Pierpaolo ; Castellana, Marco ; Piccardo, Arnoldo ; Romanelli, Francesco ; Grani, Giorgio ; Giovanella, Luca ; Durante, Cosimo

In: Reviews in endocrine and metabolic disorders, 2020, p. 8 p

Thyroid imaging reporting and data systems (TIRADS) are used to stratify the malignancy risk of thyroid nodule by ultrasound (US) examination. We conducted a meta-analysis to evaluate the pooled cancer prevalence and the relative prevalence of papillary, medullary, follicular thyroid cancer (PTC, MTC, and FTC) and other malignancies among nodules included in studies evaluating their...

Consortium of Swiss Academic Libraries

Comments on the paper by Horowitz et al. (2014)

Innocenti, G. ; Caminiti, R. ; Aboitiz, F.

In: Brain Structure and Function, 2015, vol. 220, no. 3, p. 1789-1790

Consortium of Swiss Academic Libraries

Free energies for rare events: Temperature accelerated MD and MC

Meloni, S. ; Ciccotti, G.

In: The European Physical Journal Special Topics, 2015, vol. 224, no. 12, p. 2389-2407

Università della Svizzera italiana

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia

Diop, Fary ; Moia, Riccardo ; Favini, Chiara ; Spaccarotella, Elisa ; De Paoli, Lorenzo ; Bruscaggin, Alessio ; Spina, Valeria ; Terzi-di-Bergamo, Lodovico ; Arruga, Francesca ; Tarantelli, Chiara ; Deambrogi, Clara ; Rasi, Silvia ; Adhinaveni, Ramesh ; Patriarca, Andrea ; Favini, Simone ; Sagiraju, Sruthi ; Jabangwe, Clive ; Kodipad, Ahad A. ; Peroni, Denise ; Mauro, Francesca R. ; Del Giudice, Ilaria ; Forconi, Francesco ; Cortelezzi, Agostino ; Zaja, Francesco ; Bomben, Riccardo ; Rossi, Francesca Maria ; Visco, Carlo ; Chiarenza, Annalisa ; Rigolin, Gian Matteo ; Marasca, Roberto ; Coscia, Marta ; Perbellini, Omar ; Tedeschi, Alessandra ; Laurenti, Luca ; Motta, Marina ; Donaldson, David ; Weir, Phil ; Mills, Ken ; Thornton, Patrick ; Lawless, Sarah ; Bertoni, Francesco ; Del Poeta, Giovanni ; Cuneo, Antonio ; Follenzi, Antonia ; Gattei, Valter ; Boldorini, Renzo Luciano ; Catherwood, Mark ; Deaglio, Silvia ; Foà, Robin ; Gaidano, Gianluca ; Rossi, Davide

In: Haematologica, 2020, vol. 105, no. 2, p. 448-456

BIRC3 is a recurrently mutated gene in chronic lymphocytic leukemia (CLL) but the functional implications of BIRC3 mutations are largely unexplored. Furthermore, little is known about the prognostic impact of BIRC3 mutations in CLL cohorts homogeneously treated with first-line fludarabine, cyclophosphamide, and rituximab (FCR). By immunoblotting analysis, we showed that the non-canonical...

Université de Fribourg

Bacterial oxidases of the cytochrome bd family : redox enzymes of unique structure, function, and utility as drug targets

Borisov, Vitaliy B. ; Siletsky, Sergey A. ; Paiardini, Alessandro ; Hoogewijs, David ; Forte, Elena ; Giuffrè, Alessandro ; Poole, Robert K.

In: Antioxidants & Redox Signaling, 2021, vol. 34, no. 16, p. 1280-1318

Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many ...

Université de Fribourg

Staying alive on an active volcano : 80 years population dynamics of Cytisus aeolicus (Fabaceae) from Stromboli (Aeolian Islands, Italy)

Zaia, R. ; Pasta, Salvatore ; Rita, F. Di ; Laudicina, V. A. ; Cascio, P. Lo ; Magri, D. ; Troia, Angelo ; Guarino, Riccardo

In: Ecological Processes, 2020, vol. 9, no. 1, p. 64

Cytisus aeolicus is a narrow endemic species restricted to the Aeolian archipelago (SE Tyrrhenian Sea, Italy) and it is one of the most evolutionarily isolated plants in the Mediterranean flora. Historical and literature data suggest that both metapopulations and isolated individuals of C. aeolicus are gradually shrinking. Field investigations and drone images demonstrate that the C. aeolicus...