In: Journal of Molecular Modeling, 2015, vol. 21, no. 7, p. 1-10
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In: International journal of molecular sciences, 2018, vol. 19, no. 2, p. 571
Alzheimer’s disease is the most fatal neurodegenerative disorder characterized by the aggregation and deposition of Amyloid β (Aβ) oligomers in the brain of patients. Two principal variants of Aβ exist in humans: Aβ1–40 and Aβ1–42. The former is the most abundant in the plaques, while the latter is the most toxic species and forms fibrils more rapidly. Interestingly, fibrils of...
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In: International journal of molecular sciences, 2018, vol. 19, no. 8, p. 2151
The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal Josephin domain and a disordered C-terminal tail where the polyglutamine stretch is located. Expanded ataxin-3 aggregates via a two-stage...
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In: DNA and cell biology
Hunter’s syndrome (mucopolysaccharidosis type II) is a rare X-linked lysosomal storage disorder caused by mutations in the iduronate 2-sulfatase (IDS) gene. Motivated by the case of a child affected by this syndrome, we compared the intracellular fate of wild type IDS (IDSWT) and of four nonsense mutations of IDS (IDSL482X, IDSY452X, IDSR443X and IDSW337X) generating progressively shorter ...
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In: Computational and structural biotechnology journal, 2019, vol. 17, p. 886-894
High-mobility Group Box 1 (HMGB1) is an abundant protein present in all mammalian cells and involved in several processes. During inflammation or tissue damage, HMGB1 is released in the extracellular space and, depending on its redox state, can form a heterocomplex with CXCL12. The heterocomplex acts exclusively via the chemokine receptor CXCR4 enhancing leukocyte recruitment. Here, we used...
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In: European Biophysics Journal, 2014, vol. 43, no. 10-11, p. 517-544
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Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO017.
The worldwide significant increase in life expectancy has recently drawn the attention of the scientific community to neurodegenerative pathologies of the elderly population. These neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading to intracellular inclusions or extracellular aggregates in specific brain areas. A feasible strategy to prevent...
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In: European Biophysics Journal, 2011, vol. 40, no. 1, p. 39-58
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In: Journal of Molecular Modeling, 2010, vol. 16, no. 3, p. 387-394
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In: Journal of Molecular Modeling, 2008, vol. 14, no. 10, p. 891-899
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