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Université de Fribourg

The dual pattern of corticothalamic projection of the primary auditory cortex in macaque monkey

Rouiller, Eric M. ; Durif, Caroline

In: Neuroscience Letters, 2004, vol. 358, no. 1, p. 49-52

The distribution and terminal morphology of the corticothalamic projection originating from the primary auditory cortex (A1) were established in a macaque monkey, using the anterograde (and retrograde) tracer biotinylated dextran amine. A dense corticothalamic projection from A1 was found in the ventral (vMGB) and dorsal (dMGB) divisions of the medial geniculate body and, to a lesser extent,...

Université de Fribourg

Matching the neural adaptation in the rat ventral cochlear nucleus produced by artificial (electric) and acoustic stimulation of the cochlea

Loquet, Gérard ; Pelizzone, Marco ; Valentini, Gregory ; Rouiller, Eric M.

In: Audiology and Neuro-Otology, 2004, vol. 9, p. 144-159

To investigate neural adaptive properties, near-field evoked potentials were recorded from a chronically implanted electrode in the ventral cochlear nucleus in awake Long-Evans rats exposed to acoustic stimuli or receiving intracochlear electric stimulation. Stimuli were 250-ms trains of repetitive acoustic clicks (10, 30 and 50 dB SPL) or biphasic electric pulses (30, 50 and 70 µA) with...

Université de Fribourg

About the T-system in the myofibril-free sarcoplasm of the frog muscle fibre

Voigt, Tilman ; Dauber, Wolfgang

In: Tissue and Cell, 2004, vol. 36 (4), p. 245-248

Previous investigations of the T-system in skeletal muscle fibres described the inter-myofibrillar relationships between T-tubules and the sarcoplasmic reticulum. They disregarded the arrangement of the T-system in the myofibril-free sarcoplasm in the area of muscle fibre nuclei. In the present investigation, the T-system was filled by means of lanthanum incubation and the myofibril-free...

Université de Fribourg

The strategies of the Theileria parasite: a new twist in host–pathogen interactions

Dobbelaere, Dirk AE ; Küenzi, Peter

In: Current Opinion in Immunology, 2004, vol. 16(4), p. 524-530

Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-κB (nuclear factor kappaB) activation is accomplished by recruiting the IKK (IκB kinase) complex, a central regulator of NF-κB pathways, to the...

Université de Fribourg

Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization

Schinzel, Anna ; Kaufmann, Thomas ; Borner, Christoph

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004, vol. 1644, no. 2, p. 95-105

The members of the Bcl-2 family of proteins are crucial regulators of apoptosis. In order to determine cell fate, these proteins must be targeted to distinct intracellular membranes, including the mitochondrial outer membrane (MOM), the membrane of the endoplasmic reticulum (ER) and its associated nuclear envelope. The targeting sequences and mechanisms that mediate the specificity of these...

Université de Fribourg

Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes

Schneiter, Roger ; Brügger, Britta ; Amann, Clare M. ; Prestwich, Glenn D. ; Epand, Raquel F. ; Zellnig, Günther ; Wieland, Felix T. ; Epand, Richard M.

In: Biochemical Journal, 2004, vol. 381, p. 941-949

Morphological analysis of a conditional yeast mutant in acetyl-CoA carboxylase acc1ts/mtr7, the rate-limiting enzyme of fatty acid synthesis, suggested that the synthesis of C₂₆ VLCFAs (very-long-chain fatty acids) is important for maintaining the structure and function of the nuclear membrane. To characterize this C₂₆-dependent pathway in more detail, we have now examined cells that are...

Université de Fribourg

Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae

Faergeman, Nils J. ; Feddersen, Søren ; Christiansen, Janne K. ; Larsen, Morten K. ; Schneiter, Roger ; Ungermann, Christian ; Mutenda, Kudzai ; Roepstroff, Peter ; Knudsen, Jens

In: Biochemical Journal, 2004, vol. 380, p. 907-918

In the present study, we show that depletion of acyl-CoA-binding protein, Acb1p, in yeast affects ceramide levels, protein trafficking, vacuole fusion and structure. Vacuoles in Acb1p-depleted cells are multi-lobed, contain significantly less of the SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) Nyv1p, Vam3p and Vti1p, and are unable to fuse in vitro. Mass...

Université de Fribourg

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

Dulloo, Abdul G. ; Seydoux, Josiane ; Jacquet, Jean

In: Physiology & Behavior, 2004, vol. 83, no. 4, p. 587-602

After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a...

Université de Fribourg

Cocaine-induced expression changes of axon guidance molecules in the adult rat brain

Bahi, Amine ; Dreyer, Jean-Luc

In: Molecular and Cellular Neuroscience, 2005, vol. 28(2), p. 275-291

Administration of drugs of abuse induces strong molecular adaptations and plasticity within the mesolimbic dopamine (DA) system, a pathway essential for reward-seeking behavior. Little is known about the specific targets involved in this neuroadaptation process, but there are indications that cocaine and other drugs of abuse share the ability to alter the morphology of neuronal dendrites and...

Université de Fribourg

Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

Schwaller, Beat ; Tetko, I. V. ; Tandon, P. ; Silveira, D. C. ; Vreugdenhil, M. ; Henzi, Thomas ; Potier, M. -C. ; Celio, Marco R. ; Villa, A. E. P.

In: Molecular and Cellular Neuroscience, 2004, vol. 25, no. 4, p. 650-663

Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca2+-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic seizures...