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Università della Svizzera italiana

Posterior reversible leukoencephalopathy syndrome associated with acute postinfectious glomerulonephritis : systematic review

Orlando, Corinne ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Goeggel Simonetti, Barbara ; Lava, Sebastiano A. G. ; Wyttenbach, Rolf ; Bianchetti, Mario G. ; Cristallo Lacalamita, Marirosa

In: Pediatric nephrology, 2021, p. 9

Background Kidney diseases are a recognized cause of posterior reversible leukoencephalopathy syndrome, usually abbreviated as PRES. The purpose of this review was to systematically address the association between acute postinfectious glomerulonephritis and PRES. Methods We performed a systematic review of the literature on acute postinfectious glomerulonephritis associated with PRES. The...

Università della Svizzera italiana

Recommendations on screen time, sleep and physical activity : associations with academic achievement in Swiss adolescents

Marciano, Laura ; Camerini, Anne-Linda

In: Public health, 2021, vol. 198, p. 211-217

Objectives: This study aimed to investigate how meeting international recommendations for screen time (<2 h/day), moderate-to-vigorous physical activity (MVPA; at least 60 min/day) and sleep (8e10 h/night), as well as media multitasking (MMI) as a form of screen time, impact academic achievement in early adolescence. Study design: A prospective design was used, where self-report measures...

Università della Svizzera italiana

Le malattie autoimmuni di fegato nell’adulto = Maladies auto-immunes du foie chez l’adulte

Terziroli Beretta-Piccoli, Benedetta ; De Gottardi, Andrea ; Vergani, Diego ; Mieli-Vergani, Giorgina

In: Schweizer gastroenterologie, 2021, vol. 2, no. 2, p. 56-66

Die Autoimmunhepatitis ist eine chronische Entzündung der Leber, die in jedem Lebensal- ter auftreten kann. Bei dieser Erkrankung werden erhöhte Transaminasen und Im- munglobulin G-Werte, das Vorhandensein von Autoantikörpern und Grenzzonenhepatitis (Interface-Hepatitis) bei Leberbiopsie verzeichnet. Die Therapie mit Steroiden zeigt sehr gute Ergebnisse. Wird die Krankheit nicht behandelt,...

Università della Svizzera italiana

Non-alcoholic fatty liver disease : metabolic, genetic, epigenetic and environmental risk factors

Juanola, Oriol ; Martínez-López, Sebastián ; Francés, Rubén ; Gómez-Hurtado, Isabel

In: International journal of environmental research and public health, 2021, vol. 18, no. 10, p. 24

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its...

Università della Svizzera italiana

Dexamethasone induces changes in osteogenic differentiation of human mesenchymal stromal cells via SOX9 and PPARG, but not RUNX2

Della Bella, Elena ; Buetti-Dinh, Antoine ; Licandro, Ginevra ; Ahmad, Paras ; Basoli, Valentina ; Alini, Mauro ; Stoddart, Martin J.

In: International journal of molecular sciences, 2021, vol. 22, no. 9, p. 16

Despite the huge body of research on osteogenic differentiation and bone tissue engineering, the translation potential of in vitro results still does not match the effort employed. One reason might be that the protocols used for in vitro research have inherent pitfalls. The synthetic glucocorticoid dexamethasone is commonly used in protocols for trilineage differentiation of human bone marrow...

Università della Svizzera italiana

Willingness to vaccinate against Covid-19 : a qualitative study involving older adults from Southern Switzerland

Fadda, Marta ; Suggs, L. Suzanne ; Albanese, Emiliano

In: Vaccine: X, 2021, vol. 8, p. 7

Background: The Covid-19 pandemic is causing unprecedented disruption and suffering to people across the globe, with a disproportionate toll on the elderly. The development and equitable distribution of a vaccine seems to be the most promising and sustainable route ahead. The goal of this study was to explore older adults’ attitudes towards and beliefs regarding the Covid-19 vaccination in...

Università della Svizzera italiana

Targeting glycolysis in macrophages confers protection against pancreatic ductal adenocarcinoma

Penny, Hweixian Leong ; Sieow, Je Lin ; Gun, Sin Yee ; Lau, Mai Chan ; Lee, Bernett ; Tan, Jasmine ; Phua, Cindy ; Toh, Florida ; Nga, Yvonne ; Yeap, Wei Hseun ; Janela, Baptiste ; Kumar, Dilip ; Chen, Hao ; Yeong, Joe ; Kenkel, Justin A. ; Pang, Angela ; Lim, Diana ; Toh, Han Chong ; Hon, Tony Lim Kiat ; Johnson, Christopher I. ; Khameneh, Hanif Javanmard ; Mortellaro, Alessandra ; Engleman, Edgar G. ; Rotzschke, Olaf ; Ginhoux, Florent ; Abastado, Jean-Pierre ; Chen, Jinmiao ; Wong, Siew Cheng

In: International journal of molecular sciences, 2021, vol. 22, no. 12, p. 24

Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an orthotopic mouse model of PDAC, we demonstrate that macrophages from tumor-bearing mice exhibit elevated glycolysis. Macrophage- specific deletion of Glucose Transporter 1...

Università della Svizzera italiana

Reporting of acute inflammatory neuropathies with COVID-19 vaccines : subgroup disproportionality analyses in VigiBase

Noseda, Roberta ; Ripellino, Paolo ; Ghidossi, Sara ; Bertoli, Raffaela ; Ceschi, Alessandro

In: Vaccines, 2021, vol. 9, no. 9, p. 7

Since marketing authorization, cases of neuralgic amyotrophy (NA), facial paralysis/Bell’s palsy (FP/BP), and Guillain-Barré syndrome (GBS) were reported with COVID-19 vaccines of different technologies. This study aimed to assess whether NA, FP/BP, and GBS were more frequently reported in VigiBase with COVID-19 vaccines (of any technologies) than with other viral vaccines, over the full...

Università della Svizzera italiana

Contribution of sleep disturbances to fatigue in multiple sclerosis : a prospective study using clinical and polysomnographic parameters

Riccitelli, Gianna C. ; Disanto, Giulio ; Sacco, Rosaria ; Sparasci, Davide ; Sacco, Leonardo ; Castelnovo, Anna ; Miano, Silvia ; Manconi, Mauro ; Gobbi, Claudio ; Zecca, Chiara

In: European journal of neurology, 2021, vol. 28, no. 9, p. 9

Background and purpose: Fatigue is amongst the most frequent and disabling symptoms of multiple sclerosis and a close relation between fatigue and sleep quality has been hypothesized. In this study the contribution of sleep disturbances measured by clinical and polysomnographic parameters to fatigue in multiple sclerosis was investigated. Methods: This was a prospective instrumental study...

Università della Svizzera italiana

GEASI : Geodesic-based earliest activation sites identification in cardiac models

Grandits, Thomas ; Effland, Alexander ; Pock, Thomas ; Krause, Rolf ; Plank, Gernot ; Pezzuto, Simone

In: International journal for numerical methods in biomedical engineering, 2021, vol. 37, no. 8, p. 30

The identification of the initial ventricular activation sequence is a critical step for the correct personalization of patient- specific cardiac models. In healthy conditions, the Purkinje network is the main source of the electrical activation, but under pathological conditions the so-called earliest activation sites (EASs) are possibly sparser and more localized. Yet, their number, location...