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Université de Fribourg

Elucidating the potential biological impact of cellulose nanocrystals

Camarero-Espinosa, Sandra ; Endes, Carola ; Mueller, Silvana ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Weder, Christoph ; Clift, Martin James David ; Foster, E. Johan

In: Fibers, 2016, vol. 4, no. 3, p. 21

Cellulose nanocrystals exhibit an interesting combination of mechanical properties and physical characteristics, which make them potentially useful for a wide range of consumer applications. However, as the usage of these bio-based nanofibers increases, a greater understanding of human exposure addressing their potential health issues should be gained. The aim of this perspective is to...

Université de Fribourg

Healable Supramolecular Polymer Solids

Montero de Espinosa, Lucas ; Fiore, Gina L. ; Weder, Christoph ; Foster, E. Johan ; Simon, Yoan C.

In: Progress in Polymer Science, 2015, vol. 49-50, p. 60-78

The reversible nature of non-covalent interactions between constituting building blocks permits one to temporarily disassemble supramolecular polymers through the application of an appropriate external stimulus “on command”. This framework has recently emerged as a general design strategy for the development of healable polymer systems. The approach exploits that the temporary disassembly...

Université de Fribourg

Fate of cellulose nanocrystal aerosols deposited on the lung cell surface in vitro

Endes, Carola ; Mueller, Silvana ; Kinnear, Calum ; Vanhecke, Dimitri ; Foster, E. Johan ; Petri-Fink, Alke ; Weder, Christoph ; Clift, Martin J. D. ; Rothen-Rutishauser, Barbara

In: Biomacromolecules, 2015, vol. 16, no. 4, p. 1267–1275

When considering the inhalation of high-aspect ratio nanoparticles (HARN), the characterization of their specific interaction with lung cells is of fundamental importance to help categorize their potential hazard. The aim of the present study was to assess the interaction of cellulose nanocrystals (CNCs) with a multicellular in vitro model of the epithelial airway barrier following realistic...

Université de Fribourg

An in vitro testing strategy towards mimicking the inhalation of high aspect ratio nanoparticles

Endes, Carola ; Schmid, Otmar ; Kinnear, Calum ; Mueller, Silvana ; Camarero-Espinosa, Sandra ; Vanhecke, Dimitri ; Foster, E. Johan ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Weder, Christoph ; Clift, Martin J.D.

In: Particle and Fibre Toxicology, 2015, vol. 11, no. 1, p. 40

The challenge remains to reliably mimic human exposure to high aspect ratio nanoparticles (HARN) via inhalation. Sophisticated, multi-cellular in vitro models are a particular advantageous solution to this issue, especially when considering the need to provide realistic and efficient alternatives to invasive animal experimentation for HARN hazard assessment. By incorporating a systematic test-bed...

Université de Fribourg

Risk assessment of released cellulose nanocrystals – mimicking inhalatory exposure

Endes, Carola ; Müller, S. ; Schmid, O. ; Vanhecke, Dimitri ; Foster, E. Johan ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Weder, Christoph ; Clift, Martin J. D.

In: Journal of Physics: Conference Series, 2013, vol. 429, no. 1, p. 012008

Cellulose nanocrystals (CNCs) exhibit advantageous chemical and mechanical properties that render them attractive for a wide range of applications. During the life-cycle of CNC containing materials the nanocrystals could be released and become airborne, posing a potential inhalatory exposure risk towards humans. Absent reliable and dose-controlled models that mimic this exposure in situ is a...

Université de Fribourg

Investigating the interaction of cellulose nanofibers derived from cotton with a sophisticated 3D human lung cell coculture

Clift, Martin J. D. ; Foster, E. Johan ; Vanhecke, Dimitri ; Studer, Daniel ; Wick, Peter ; Gehr, Peter ; Rothen-Rutishauser, Barbara ; Weder, Christoph

In: Biomacromolecules, 2011, vol. 12, no. 10, p. 3666–3673

Cellulose nanofibers are an attractive component of a broad range of nanomaterials. Their intriguing mechanical properties and low cost, as well as the renewable nature of cellulose make them an appealing alternative to carbon nanotubes (CNTs), which may pose a considerable health risk when inhaled. Little is known, however, concerning the potential toxicity of aerosolized cellulose nanofibers....

Université de Fribourg

Bioinspired mechanically adaptive polymer nanocomposites with water-activated shape-memory effect

Mendez, Julie ; Annamalai, Pratheep K. ; Eichhorn, Stephen J. ; Rusli, Rafeadah ; Rowan, Stuart J. ; Foster, E. Johan ; Weder, Christoph

In: Macromolecules, 2011, vol. 44, no. 17, p. 6827–6835

New biomimetic, stimuli-responsive mechanically adaptive nanocomposites, which change their mechanical properties upon exposure to water and display a water-activated shape-memory effect, were investigated. These materials were produced by introducing rigid cotton cellulose nanowhiskers (CNWs) into a rubbery polyurethane (PU) matrix. A series of materials with CNW concentrations of 2–20% v/v...

Université de Fribourg

Biologically inspired hierarchical design of nanocomposites based on poly(ethylene oxide) and cellulose nanofibers

Changsarn, Sutheerat ; Mendez, James D. ; Shanmuganathan, Kadhiravan ; Foster, E. Johan ; Weder, Christoph ; Supaphol, Pitt

In: Macromolecular Rapid Communications, 2011, vol. 32, no. 17, p. 1367–1372

Attempts to create hierarchically structured, uniaxially oriented nanocomposites comprising cellulose nanowhiskers (CNWs), which promise anisotropic mechanical properties, are exceedingly rare. We report here the fabrication of uniaxially-oriented arrays of microfibers based on poly(ethylene oxide) (PEO) and CNWs by electrospinning. Compared with the neat PEO fibers, the incorporation of CNWs...