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    Université de Fribourg

    Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

    Schwaller, Beat ; Tetko, I. V. ; Tandon, P. ; Silveira, D. C. ; Vreugdenhil, M. ; Henzi, Thomas ; Potier, M. -C. ; Celio, Marco R. ; Villa, A. E. P.

    In: Molecular and Cellular Neuroscience, 2004, vol. 25, no. 4, p. 650-663

    Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca2+-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic seizures...