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Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter

Templin, Christian ; Jaguszewski, Milosz ; Ghadri, Jelena R. ; Sudano, Isabella ; Gaehwiler, Roman ; Hellermann, Jens P. ; Schoenenberger-Berzins, Renate ; Landmesser, Ulf ; Erne, Paul ; Noll, Georg ; Lüscher, Thomas F.

In: European Heart Journal, 2013, vol. 34, no. 28, p. 2141-2148

Increasing high-density lipoprotein cholesterol by cholesteryl ester transfer protein-inhibition: a rocky road and lessons learned? The early demise of the dal-HEART programme

Landmesser, Ulf ; von Eckardstein, Arnold ; Kastelein, John ; Deanfield, John ; Lüscher, Thomas F.

In: European Heart Journal, 2012, vol. 33, no. 14, p. 1712-1715

PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design

Holy, Erik W. ; Jakob, Philipp ; Eickner, Thomas ; Camici, Giovanni G. ; Beer, Jürg H. ; Akhmedov, Alexander ; Sternberg, Katrin ; Schmitz, Klaus-Peter ; Lüscher, Thomas F. ; Tanner, Felix C.

In: European Heart Journal, 2014, vol. 35, no. 12, p. 808-820

Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study

Räber, Lorenz ; Taniwaki, Masanori ; Zaugg, Serge ; Kelbæk, Henning ; Roffi, Marco ; Holmvang, Lene ; Noble, Stephane ; Pedrazzini, Giovanni ; Moschovitis, Aris ; Lüscher, Thomas F. ; Matter, Christian M. ; Serruys, Patrick W. ; Jüni, Peter ; Garcia-Garcia, Hector M. ; Windecker, Stephan

In: European Heart Journal, 2015, vol. 36, no. 8, p. 490-500

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Miranda, Melroy X. ; van Tits, Lambertus J. ; Lohmann, Christine ; Arsiwala, Tasneem ; Winnik, Stephan ; Tailleux, Anne ; Stein, Sokrates ; Gomes, Ana P. ; Suri, Vipin ; Ellis, James L. ; Lutz, Thomas A. ; Hottiger, Michael O. ; Sinclair, David A. ; Auwerx, Johan ; Schoonjans, Kristina ; Staels, Bart ; Lüscher, Thomas F. ; Matter, Christian M.

In: European Heart Journal, 2015, vol. 36, no. 1, p. 51-59

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression

Reiner, Martin F. ; Akhmedov, Alexander ; Stivala, Simona ; Keller, Stephan ; Gaul, Daniel S. ; Bonetti, Nicole R. ; Savarese, Gianluigi ; Glanzmann, Martina ; Zhu, Cuicui ; Ruf, Wolfram ; Yang, Zhihong ; Matter, Christian M. ; Lüscher, Thomas F. ; Camici, Giovanni G. ; Beer, Juerg H.

In: Cardiovascular Research, 2017, vol. 113, no. 1, p. 61–69

The P2Y12 antagonist ticagrelor reduces mortality in patients with acute coronary syndrome (ACS), compared with clopidogrel, and the mechanisms underlying this effect are not clearly understood. Arterial thrombosis is the key event in ACS; however, direct vascular effects of either ticagrelor or clopidogrel with focus on arterial thrombosis and its key trigger tissue factor have not been...

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Gebhard, C. ; Holy, E. W. ; Camici, Giovanni G. ; Akhmedov, Alexander ; Stämpfli, S. F. ; Stähli, B. E. ; Rickenbach, B. von ; Breitenstein, A. ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Thrombosis and Haemostasis, 2012, vol. 107, no. 5, p. 803-1007

Tissue factor (TF) is the key activator of coagulation and is involved in acute coronary syndromes. Caffeine is often reported to increase cardiovascular risk; however, its effect on cardiovascular morbidity and mortality is controversial. Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro . Caffeine concentration-dependently enhanced TF...

Endothelial nitric oxide synthase gene transfer inhibits human smooth muscle cell migration via inhibition of Rho A

Largiadèr, Thomas ; Eto, Masato ; Payeli, Sravan K. ; Greutert, Helen ; Viswambharan, Hema ; Lachat, Mario ; Zünd, Gregor ; Yang, Zhihong ; Tanner, Felix C. ; Lüscher, Thomas F.

In: Journal of Cardiovascular Pharmacology, 2008, vol. 52, no. 4, p. 369-374

Smooth muscle cell (SMC) migration contributes to vascular remodeling. Nitric oxide (NO) produced via endothelial NO synthase (eNOS) inhibits SMC migration. This study analyzes signal transduction mechanisms of SMC migration targeted by NO. SMCs were cultured from human saphenous veins, and cell migration was studied using Boyden chambers. PDGF-BB (0.1 to 10 ng/ml) stimulated SMC migration in a...

Different vascular smooth muscle cell apoptosis in the human internal mammary artery and the saphenous vein: implications for bypass graft disease

Frischknecht, Karin ; Greutert, Helen ; Weisshaupt, Christian ; Kaspar, Mathias ; Yang, Zhihong ; Lüscher, Thomas F. ; Carrel, Thierry P. ; Tanner, Felix C.

In: Journal of Vascular Research, 2006, vol. 43, no. 4, p. 338-346

The remarkable patency of internal mammary artery (MA) grafts compared to saphenous vein (SV) grafts has been related to different biological properties of the two blood vessels. We examined whether proliferation and apoptosis of vascular smooth muscle cells (VSMC) from human coronary artery bypass vessels differ according to patency rates. Methods and Results: Proliferation rates to serum...

Dimethyl sulfoxide inhibits tissue factor expression, thrombus formation, and vascular smooth muscle cell activation: a potential treatment strategy for drug-eluting stents

Camici, Giovanni G. ; Steffel, Jan ; Akhmedov, Alexander ; Schafer, Nicola ; Baldinger, Jeannette ; Schulz, Urs ; Shojaati, Kushiar ; Matter, Christian M. ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Circulation, 2006, vol. 114, no. 14, p. 1512-1521

Background— Subacute stent thrombosis is a major clinical concern, and the search for new molecules to cover stents remains important. Dimethyl sulfoxide (DMSO) is used for preservation of hematopoietic progenitor cells and is infused into patients undergoing bone marrow transplantation. Despite its intravenous application, the impact of DMSO on vascular cells has not been assessed....