In: Supportive Care in Cancer, 2003, vol. 11, no. 10, p. 666-673
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In: European Journal of Nutrition, 2012, vol. 51, no. 4, p. 407-413
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In: Supportive Care in Cancer, 2011, vol. 19, no. 2, p. 271-279
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In: Surgical Endoscopy, 2015, vol. 29, no. 11, p. 3363-3366
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Mémoire de diplôme HES : Haute Ecole de Travail Social, 2008.
Ce travail de mémoire traite de la mobilisation des ressources et de la participation des personnes atteintes d’un cancer, par le biais des thérapies complémentaires. Pour ce faire, j’ai interrogé dix personnes ayant utilisé les méthodes non-traditionnelles dans le combat de la maladie. Le but de ce travail est d’évaluer les raisons qui les ont poussées à y avoir recours et...
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In: International journal of molecular sciences, 2018, vol. 19, no. 6, p. 1591
Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific “signal transducer and activator of transcription” (STAT3) factor that is involved in several pathologies, including cancer....
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In: European Journal of Cardio-Thoracic Surgery, 2012, vol. 41, no. 3, p. 612-616
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In: Supportive Care in Cancer, 2015, vol. 23, no. 7, p. 1837-1839
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In: Cell reports, 2018, vol. 23, no. 1, p. 39-49
In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell- specific Shp-2-deficient mice. These...
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In: Frontiers in immunology, 2019, vol. 10, no. 2468, p. 1-11
Somewhat counterintuitively, the tyrosine phosphatase SHP-2 (SH2 domain- containing protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated kinase (ERK) downstream of various growth factor receptors, thereby exerting essential developmental functions. This phosphatase also deploys proto-oncogenic functions and specific inhibitors have recently been ...
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