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Université de Fribourg

When plants and plastic interact

Schwab, Fabienne ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nature Nanotechnology, 2020, vol. 15, no. 9, p. 729–730

Overcoming the challenges of plastic detection in plants has made it possible to transfer many of the lessons learned from plant–metal nanoparticle interactions to plastic nanoparticles.

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...

Université de Fribourg

Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro

Fytianos, Kleanthis ; Rodriguez-Lorenzo, Laura ; Clift, Martin J.D. ; Blank, Fabian ; Vanhecke, Dimitri ; Garnier, Christophe von ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Nanomedicine: Nanotechnology, Biology and Medicine, 2015, vol. 11, no. 3, p. 633–644

Engineering nanoparticles (NPs) for immune modulation require a thorough understanding of their interaction(s) with cells. Gold NPs (AuNPs) were coated with polyethylene glycol (PEG), polyvinyl alcohol (PVA) or a mixture of both with either positive or negative surface charge to investigate uptake and cell response in monocyte-derived dendritic cells (MDDCs). Inductively coupled plasma optical...

Université de Fribourg

Uptake and intracellular fate of peptide surface-functionalized silica hybrid magnetic nanoparticles in vitro

Digigow, Reinaldo G. ; Vanhecke, Dimitri ; Rothen-Rutishauser, Barbara ; Clift, Martin J.D. ; Petri-Fink, Alke

In: Particle & Particle Systems Characterization, 2015, vol. 32, no. 2, p. 188–196

Recently, the use of nanomaterials as intracellular targeting tools for theranostics has gained heightened interest. Despite the clear advantages posed by surface-functionalized nanoparticles (NPs) in this regard, limited understanding currently exists due to difficulties in reliably synthesizing NPs with surface functionalizations adequate for use in such applications, as well as the manner of...

Université de Fribourg

Understanding the assembly of amphiphilic additives in bulk and dispersed non-lamellar lipid-based matrices: Phosphorylation, H-bonding and ionisation

F.Etter, Marco ; Dellenbach, Daria ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; M.Landau, Ehud ; Fong, Wye-Khay

In: Journal of Colloid and Interface Science, 2020, vol. 562, p. 502–510

The aqueous channel size of lipidic cubic phases can be a limiting factor for certain applications. For this reason, additives have been used to exquisitely control their nanostructure. In this study, two families of primary phosphoesters have been designed, synthesised and utilised to determine the effect of the positioning of the guest additive at the interface of the host mesophase, and to...

Université de Fribourg

Ultrathin ceramic membranes as scaffolds for functional cell coculture models on a biomimetic scale

Jud, Corinne ; Ahmed, Sher ; Müller, Loretta ; Kinnear, Calum ; Vanhecke, Dimitri ; Umehara, Yuki ; Frey, Sabine ; Liley, Martha ; Angeloni, Silvia ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: BioResearch Open Access, 2015, vol. 4, no. 1, p. 457–468

Epithelial tissue serves as an interface between biological compartments. Many in vitro epithelial cell models have been developed as an alternative to animal experiments to answer a range of research questions. These in vitro models are grown on permeable two-chamber systems; however, commercially available, polymer-based cell culture inserts are around 10 μm thick. Since the basement...

Université de Fribourg

Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

Bachler, Gerald ; Losert, Sabrina ; Umehara, Yuki ; Goetz, Natalie von ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hungerbuehler, Konrad

In: Particle and Fibre Toxicology, 2015, vol. 12, no. 1, p. 18

The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very little is known about factors that determine the pulmonary translocation of NPs and their subsequent distribution to secondary...

Université de Fribourg

Thermally reversible self-assembly of nanoparticles via polymer crystallization

Kinnear, Calum ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Macromolecular Rapid Communications, 2014, vol. 35, no. 23, p. 2012–2017

The directed self-assembly of gold nanoparticles through the crystallization of surface-grafted polyethylene oxide (PEO) in ethanol–water mixtures is described. This process is fully reversible and tunable through either the size of the core or the polymeric coating. Characterization by X-ray scattering and electron microscopy of the self-assembled structures reveals order at the nanoscale,...