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Université de Fribourg

Aerosol delivery of functionalized gold nanoparticles target and activate dendritic cells in a 3D lung cellular model

Fytianos, Kleanthis ; Chortarea, Savvina ; Rodriguez-Lorenzo, Laura ; Blank, Fabian ; Garnier, Christophe von ; Petri-Fink, Alke ; Rothen-Rutishauser, and Barbara

In: ACS Nano, 2017, vol. 11, no. 1, p. 375–383

Nanocarrier design combined with pulmonary drug delivery holds great promise for the treatment of respiratory tract disorders. In particular, targeting of dendritic cells that are key immune cells to enhance or suppress an immune response in the lung is a promising approach for the treatment of allergic diseases. Fluorescently encoded poly(vinyl alcohol) (PVA)-coated gold nanoparticles,...

Université de Fribourg

Artificial lysosomal platform to study nanoparticle long-term stability

Milosevic, Ana ; Bourquin, Joël ; Burnand, David ; Lemal, Philipp ; Crippa, Federica ; Monnier, Christophe A. ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 55–58

Nanoparticles (NPs) possess unique properties useful for designing specific functionalities for biomedi- cal applications. A prerequisite of a safe-by-design and effective use in any biomedical application is to study NP–cell interactions to gain a better understanding of cellular consequences upon exposure. Cellular uptake of NPs results mainly in the localization of NPs in the complex...

Université de Fribourg

Assessing meso- and microplastic pollution in the Ligurian and Tyrrhenian Seas

Caldwell, Jessica ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Lehner, Roman

In: Marine Pollution Bulletin, 2019, vol. 149, p. 110572

As the production of plastic products continues to increase, determining the fate of plastic waste in the environment is of high importance. Densely populated areas, such as Mediterranean coastlines, represent locations of high pollution risk for surrounding environments. Thus, this study aims to assess the abundance, size, and composition of floating meso- and microplastics collected during...

Université de Fribourg

Assessment of lung cell toxicity of various gasoline engine exhausts using a versatile in vitro exposure system

Bisig, Christoph ; Comte, Pierre ; Güdel, Martin ; Czerwinski, Jan ; Mayer, Andreas ; Müller, Loretta ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Environmental Pollution, 2018, vol. 235, p. 263–271

Adverse effect studies of gasoline exhaust are scarce, even though gasoline direct injection (GDI) vehicles can emit a high number of particles. The aim of this study was to conduct an in vitro hazard assessment of different GDI exhausts using two different cell culture models mimicking the human airway. In addition to gasoline particle filters (GPF), the effects of two lubrication oils with...

Université de Fribourg

Assessment of the potential for in-plume sulphur dioxide gas-ash interactions to influence the respiratory toxicity of volcanic ash

Tomašek, Ines ; Damby, David E. ; Horwell, Claire J. ; Ayris, Paul M. ; Delmelle, Pierre ; Ottley, Christopher J. ; Cubillas, Pablo ; Casas, Ana S. ; Bisig, Christoph ; Petri-Fink, Alke ; Dingwell, Donald B. ; Clift, Martin J. D. ; Drasler, Barbara ; Rothen-Rutishauser, Barbara

In: Environmental Research, 2019, vol. 179, p. 108798

Volcanic plumes are complex environments composed of gases and ash particles, where chemical and physical processes occur at different temperature and compositional regimes. Commonly, soluble sulphate- and chloride-bearing salts are formed on ash as gases interact with ash surfaces. Exposure to respirable volcanic ash following an eruption is potentially a significant health concern. The...

Université de Fribourg

Assumption-free morphological quantification of single anisotropic nanoparticles and aggregates

Vanhecke, Dimitri ; Rodríguez-Lorenzo, Laura ; Kinnear, Calum ; Durantie, Estelle ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2017, vol. 9, no. 15, p. 4918–4927

Characterizing the morphometric parameters of noble metal nanoparticles for sensing and catalysis is a persistent challenge due to their small size and complex shape. Herein, we present an approach to determine the volume, surface area, and curvature of non-symmetric anisotropic nanoparticles using electron tomography and design- based stereology without the use of segmentation tools or...

Université de Fribourg

An atomistic look into bio-inspired nanoparticles and their molecular interactions with cells

Petretto, Emanuele ; Campomanes, Pablo ; Stellacci, Francesco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Vanni, Stefano

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 78–80

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequently interact with various endomembranes. Unlike pathogens, however, NPs lack the remarkable specificity gained during the evolutionary...