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Calcium antagonist induced vasodilation in peripheral, coronary and cerebral vasculature as important factors in the treatment of elderly hypertensives

Erne, P. ; Conen, D. ; Kiowski, W. ; Bolli, P. ; Müller, F. B. ; Bühler, F. R.

In: European Heart Journal, 1987, vol. 8, p. 49-56

Rapid turnover of the “functional” Na⁺–Ca²⁺ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach

Egger, Marcel ; Porzig, Hartmut ; Niggli, Ernst ; Schwaller, Beat

In: Cell Calcium, 2005, vol. 37, no. 3, p. 233-243

Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na⁺–Ca²⁺ exchanger (NCX1) to correlate suppression of the Na⁺–Ca²⁺ exchange function with down-regulation of NCX1 protein expression. In a de-novo expression system (Sf9 cells), a decrease in both, NCX1 mRNA and protein after AS-ODN application was paralleled by...