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Methionine metabolism in an animal model of sepsis

Semmler, Alexander ; Smulders, Yvo ; Struys, Eduard ; Smith, Desiree ; Moskau, Susanna ; Blom, Henk ; Linnebank, Michael

In: Clinical Chemistry and Laboratory Medicine, 2008, vol. 46, no. 10, p. 1398-1402

Université de Fribourg

Disease resistance of Arabidopsis to Phytophthora brassicae is established by the sequential action of indole glucosinolates and camalexin

Schlaeppi, Klaus ; Abou-Mansour, Eliane ; Buchala, Antony J. ; Mauch, Felix

In: The Plant Journal, 2010, vol. 62, no. 5, p. 840 - 851

We have analysed the role of tryptophan-derived secondary metabolites in disease resistance of Arabidopsis to the oomycete pathogen Phytophthora brassicae. Transcript analysis revealed that genes encoding enzymes involved in tryptophan, camalexin and indole glucosinolate (iGS) biosynthesis are coordinately induced in response to P. brassicae. However, a deficiency in either camalexin or iGS...

Université de Fribourg

In vivo over-expression of interleukin-10 increases resistance to focal brain ischemia in mice

Bilbao, Fabienne de ; Arsenijevic, Denis ; Moll, Thomas ; Garcia-Gabay, Irene ; Vallet, Philippe ; Langhans, Wolfgang ; Giannakopoulos, Panteleimon

In: Journal of Neurochemistry, 2009///doi: 10.1111/j.1471-4159.2009.06098.x

Early studies showed that the administration of the anti-inflammatory cytokine interleukin-10 (IL10) protects against permanent middle cerebral artery occlusion (MCAO) in mice. In this study, transgenic mice expressing murine IL10 (IL10T) directed by the major histocompatibility complex Ea promoter were produced and used to explore the effect of chronically increased IL10 levels on MCAO-related...

Université de Fribourg

Subcellular immunocytochemical analysis detects the highest concentrations of glutathione in mitochondria and not in plastids

Zechmann, B. ; Mauch, Felix ; Sticher, Liliane ; Müller, M.

In: Journal of Experimental Botany, 2008, vol. 59, no. 14, p. 4017-4027

The tripeptide glutathione is a major antioxidant and redox buffer with multiple roles in plant metabolism. Glutathione biosynthesis is restricted to the cytosol and the plastids and the product is distributed to the various organelles by unknown mechanisms. In the present study immunogold cytochemistry based on anti-glutathione antisera and transmission electron microscopy was used to...