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Université de Fribourg

The role of lipids in the biogenesis of integral membrane proteins

Schneiter, Roger ; Toulmay, Alexandre

In: Applied Microbiology and Biotechnology, 2007, vol. 73, no. 6, p. 1224-1232

Most integral membrane proteins are cotranslationally inserted into the lipid bilayer. In prokaryotes, membrane insertion of the nascent chain takes place at the plasma membrane, whereas in eukaryotes insertion takes place into the endoplasmatic reticulum. In both kingdoms of life, however, the same membrane that acquaints the newly born membrane protein also synthesizes the bilayer lipids...