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Wnt signaling: multiple functions in neural development

Ille, F. ; Sommer, L.

In: Cellular and Molecular Life Sciences CMLS, 2005, vol. 62, no. 10, p. 1100-1108

Peutz-Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling

Lin-Marq, Nathalie ; Borel, Christelle ; Antonarakis, Stylianos

In: Molecular Genetics and Genomics, 2005, vol. 273, no. 2, p. 184-196

Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro

Groll, Nicola ; Petrikat, Tamara ; Vetter, Silvia ; Wenz, Christine ; Dengjel, Jörn ; Gretzmeier, Christine ; Weiss, Frederik ; Poetz, Oliver ; Joos, Thomas O. ; Schwarz, Michael ; Braeuning, Albert

In: Toxicology, 2016, vol. 370, p. 94-105

The antiepileptic drug phenobarbital (PB) exerts hepatic effect based on indirect activation of the constitutive androstane receptor (CAR) via inhibition of the epidermal growth factor receptor (EGFR) and the kinase Src. It has furthermore been observed that in mice PB suppresses the growth of hepatocellular carcinoma with overactive signaling through the oncogenic Wnt/β-catenin pathway,...

Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells

Zaric, J. ; Joseph, J.-M. ; Tercier, S. ; Sengstag, T. ; Ponsonnet, L. ; Delorenzi, M. ; Rüegg, Curzio

In: Oncogene, 2012, vol. 31, p. 48-59

Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors (COXIBs) reduces the risk of cancer development and progression, in particular of the colon. The COXIB...