In: Current Neurology and Neuroscience Reports, 2013, vol. 13, no. 12, p. 1-8
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In: Acta Neuropathologica, 2008, vol. 115, no. 1, p. 39-53
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In: Journal of Molecular Medicine, 2008, vol. 86, no. 11, p. 1255-1267
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In: Acta Neuropathologica Communications, 2016, vol. 4, p. 64
Background: Notch1 signaling is a cellular cascade with a fundamental role from brain development to adult brain function. Reduction in Notch1 affects synaptic plasticity, memory and olfaction. On the other hand, Notch1 overactivation after brain injury is detrimental for neuronal survival. Some familial Alzheimer’s disease (FAD) mutations in Presenilins can affect Notch1...
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