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Measuring multiple neurochemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography-mass spectrometry

Li, Juan ; von Pföstl, Veronika ; Zaldivar, Daniel ; Zhang, Xiaozhe ; Logothetis, Nikos ; Rauch, Alexander

In: Analytical and Bioanalytical Chemistry, 2012, vol. 402, no. 8, p. 2545-2554

Measuring multiple neurochemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography–mass spectrometry

Li, Juan ; Pföstl, Veronika von ; Zaldivar, Daniel ; Zhang, Xiaozhe ; Logothetis, Nikos ; Rauch, Alexander

In: Analytical and Bioanalytical Chemistry, 2012, p. -

In vivo measurement of multiple functionally related neurochemicals and metabolites (NMs) is highly interesting but remains challenging in the field of basic neuroscience and clinical research. We present here an analytical method for determining five functionally and metabolically related polar substances, including acetylcholine (quaternary ammonium), lactate and pyruvate (organic acids), as...