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Università della Svizzera italiana

TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities

Montagner, Sara ; Leoni, Cristina ; Emming, Stefan ; Della Chiara, Giulia ; Balestrieri, Chiara ; Barozzi, Iros ; Piccolo, Viviana ; Togher, Susan ; Ko, Myunggon ; Rao, Anjana ; Natoli, Gioacchino ; Monticelli, Silvia

In: Cell reports, 2016, vol. 15, no. 7, p. 1566-1579

Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation. In the absence of TET2, mast cells showed disrupted gene expression and altered genome-wide 5hmC deposition, especially at enhancers and in the proximity of...

Consortium of Swiss Academic Libraries

PI3Kinase signaling in glioblastoma

Lino, M. ; Merlo, A.

In: Journal of Neuro-Oncology, 2011, vol. 103, no. 3, p. 417-427

Consortium of Swiss Academic Libraries

SHH Pathway and Cerebellar Development

Vaillant, Catherine ; Monard, Denis

In: The Cerebellum, 2009, vol. 8, no. 3, p. 291-301