Université de Fribourg

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities

Wider, Diana ; Péli-Gulli, Marie-Pierre ; Briand, Pierre-André ; Tatu, Utpal ; Picard, Didier

In: Molecular and Biochemical Parasitology, 2009, vol. 164, no. 2, p. 147-152

Developing novel drugs against the unicellular parasite Plasmodium is complicated by the paucity of simple screening systems. Heat-shock proteins are an essential class of proteins for the parasite's cyclical life style between different cellular milieus and temperatures. The molecular chaperone Hsp90 assists a large variety of proteins, but its supporting functions for many proteins that are...

Université de Fribourg

Functional significance of triazine-herbicide resistance in defence of Senecio vulgaris against a rust fungus

Salzmann, Daniel ; Handley, Richard J. ; Müller-Schärer, Heinz

In: Basic and Applied Ecology, 2008, vol. 9, no. 5, p. 577-587

We investigated the functional significance of plant performance (dry mass, photosynthesis) in plant defence (resistance and tolerance) against pathogen infection, and potential negative cross-resistance between herbicide resistance and plant defence against disease. We compared isonuclear triazine-herbicide-resistant (TR) and -susceptible (TS) biotypes of Senecio vulgaris, in the presence and...