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SHP-2 in lymphocytes’ cytokine and inhibitory receptor signaling

Niogret, Charlène ; Birchmeier, Walter ; Guarda, Greta

In: Frontiers in immunology, 2019, vol. 10, no. 2468, p. 1-11

Somewhat counterintuitively, the tyrosine phosphatase SHP-2 (SH2 domain- containing protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated kinase (ERK) downstream of various growth factor receptors, thereby exerting essential developmental functions. This phosphatase also deploys proto-oncogenic functions and specific inhibitors have recently been ...

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

Muenst, S. ; Schaerli, A. ; Gao, F. ; Däster, S. ; Trella, E. ; Droeser, R. ; Muraro, M. ; Zajac, P. ; Zanetti, R. ; Gillanders, W. ; Weber, W. ; Soysal, S.

In: Breast Cancer Research and Treatment, 2014, vol. 146, no. 1, p. 15-24

The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer

Muenst, S. ; Soysal, S. ; Gao, F. ; Obermann, E. ; Oertli, D. ; Gillanders, W.

In: Breast Cancer Research and Treatment, 2013, vol. 139, no. 3, p. 667-676

Suppressed T-cell activation by IFN-γ-induced expression of PD-L1 on renal tubular epithelial cells

Schoop, Roland ; Wahl, Patricia ; Le Hir, Michel ; Heemann, Uwe ; Wang, Minghui ; Wüthrich, Rudolf P.

In: Nephrology Dialysis Transplantation, 2004, vol. 19, no. 11, p. 2713-2720