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Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity

Liaudet, Lucas ; Calderari, Belinda ; Pacher, Pal

In: Heart Failure Reviews, 2014, vol. 19, no. 6, p. 815-824

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Genini, Davide ; Brambilla, Lara ; Laurini, Erik ; Merulla, Jessica ; Civenni, Gianluca ; Pandit, Shusil ; D'Antuono, Rocco ; Perez, Laurent ; Levy, David E. ; Pricl, Sabrina ; Carbone, Giuseppina M. ; Catapano, Carlo V.

In: Proceedings of the national academy of sciences of the United States of America, 2017, vol. 114, no. 25, p. E4924-E4933

In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of mitochondrial function. Here, we demonstrate that a novel inhibitor that binds with high affinity to the STAT3 SH2 domain triggers a complex cascade of events initiated by interference with mitochondrial STAT3 (mSTAT3). The...

Cardiovascular determinants of life span

Shi, Yi ; Camici, Giovanni ; Lüscher, Thomas

In: Pflügers Archiv - European Journal of Physiology, 2010, vol. 459, no. 2, p. 315-324

Regulation of the mitochondrial proton gradient by cytosolic Ca2+ signals

Poburko, Damon ; Demaurex, Nicolas

In: Pflügers Archiv - European Journal of Physiology, 2012, vol. 464, no. 1, p. 19-26

NADH oxidation drives respiratory Na+ transport in mitochondria from Yarrowia lipolytica

Lin, Po-Chi ; Puhar, Andrea ; Steuber, Julia

In: Archives of Microbiology, 2008, vol. 190, no. 4, p. 471-480

Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1

Galetti, Sandrine ; Sarre, Alexandre ; Perreten, Hélène ; Produit-Zengaffinen, Nathalie ; Muzzin, Patrick ; Assimacopoulos-Jeannet, Françoise

In: Pflügers Archiv - European Journal of Physiology, 2009, vol. 457, no. 4, p. 931-940

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

Eckert, Anne ; Schulz, Kathrin ; Rhein, Virginie ; Götz, Jürgen

In: Molecular Neurobiology, 2010, vol. 41, no. 2-3, p. 107-114

The link between iron, metabolic syndrome, and Alzheimer's disease

Grünblatt, Edna ; Bartl, Jasmin ; Riederer, Peter

In: Journal of Neural Transmission, 2011, vol. 118, no. 3, p. 371-379

Glutathione depletion and increased apoptosis rate in human cystinotic proximal tubular cells

Laube, Guido ; Shah, Vanita ; Stewart, Victoria ; Hargreaves, Iain ; Haq, Mushfequr ; Heales, Simon ; van't Hoff, William

In: Pediatric Nephrology, 2006, vol. 21, no. 4, p. 503-509

Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous Relationship

Grimm, Amandine ; Lim, Yun-An ; Mensah-Nyagan, Ayikoe ; Götz, Jürgen ; Eckert, Anne

In: Molecular Neurobiology, 2012, vol. 46, no. 1, p. 151-160