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Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy

Morgado, Leonor ; Zeth, Kornelius ; Burmann, Björn ; Maier, Timm ; Hiller, Sebastian

In: Journal of Biomolecular NMR, 2015, vol. 61, no. 3-4, p. 333-345

Influenza hemagglutinin membrane anchor

Benton, Donald J. ; Nans, Andrea ; Calder, Lesley J. ; Turner, Jack ; Neu, Ursula ; Lin, Yi Pu ; Ketelaars, Esther ; Kallewaard, Nicole L. ; Corti, Davide ; Lanzavecchia, Antonio ; Gamblin, Steven J. ; Rosenthal, Peter B. ; Skehel, John J.

In: Proceedings of the national academy of sciences of the United States of America, 2018, vol. 115, no. 40, p. 10112-10117

Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the “membrane anchor” portion of the...

Membrane protein dynamics in different environments: simulation study of the outer membrane protein X in a lipid bilayer and in a micelle

Choutko, Alexandra ; Glättli, Alice ; Fernández, César ; Hilty, Christian ; Wüthrich, Kurt ; van Gunsteren, Wilfred

In: European Biophysics Journal, 2011, vol. 40, no. 1, p. 39-58

The active site of yeast phosphatidylinositol synthase Pis1 is facing the cytosol

Bochud, Arlette ; Conzelmann, Andreas

In: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015, vol. 1851, no. 5, p. 629–640

Five yeast enzymes synthesizing various glycerophospholipids belong to the CDP-alcohol phosphatidyltransferase (CAPT) superfamily. They only share the so-called CAPT motif, which forms the active site of all these enzymes. Bioinformatic tools predict the CAPT motif of phosphatidylinositol synthase Pis1 as either ER luminal or cytosolic. To investigate the membrane topology of Pis1, unique...