In: International Journal of Legal Medicine, 2015, vol. 129, no. 1, p. 97-103
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In: Cell reports, 2016, vol. 15, no. 7, p. 1566-1579
Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation. In the absence of TET2, mast cells showed disrupted gene expression and altered genome-wide 5hmC deposition, especially at enhancers and in the proximity of...
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In: International Journal of Legal Medicine, 2014, vol. 128, no. 1, p. 95-103
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In: Archives of Dermatological Research, 2014, vol. 306, no. 10, p. 933-938
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In: Molecular and cellular biology, 2012, vol. 32, no. 21, p. 4432-4444
The transcription factor NF-κB regulates the expression of a broad number of genes central to immune and inflammatory responses. We identified a new molecular network that comprises specifically the NF-κB family member NF-κB1 (p50) and miR-146a, and we show that in mast cells it contributes to the regulation of cell homeostasis and survival, while in T lymphocytes it modulates T cell...
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In: Proceedings of the national academy of sciences, 2017, vol. 114, no. 8, p. E1490-E1499
DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in DNMT3A correlate with mast cell proliferative disorders in humans, the role of DNA methylation in mast cell biology is not understood. By using...
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In: Archives of Dermatological Research, 2005, vol. 296, no. 10, p. 503-506
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In: Apoptosis, 2009, vol. 14, no. 4, p. 439-446
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In: Archivum Immunologiae et Therapiae Experimentalis, 2010, vol. 58, no. 4, p. 279-286
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