Université de Fribourg

Separation and identification of mouse brain tissue microproteins using top‐down method with high resolution nanocapillary liquid chromatography mass spectrometry

Li, Wenxue ; Petruzziello, Filomena ; Zhao, Nan ; Zhao, Huiyuan ; Ye, Xueting ; Zhang, Xiaozhe ; Rainer, Gregor

In: PROTEOMICS, 2017, vol. 17, no. 12, p. -

Microproteins and endogenous peptides in the brain contain important substances that have critical roles in diverse biological processes, contributing to signal transduction and intercellular signaling. However, variability in their physical or chemical characteristics, such as molecule size, hydrophobicity, and charge states, complicate the simultaneous analysis of these compounds, although...