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Brain natriuretic peptide is able to stimulate cardiac progenitor cell proliferation and differentiation in murine hearts after birth

Bielmann, Christelle ; Rignault-Clerc, Stéphanie ; Liaudet, Lucas ; Li, Feng ; Kunieda, Tetsuo ; Sogawa, Chizuru ; Zehnder, Tamara ; Waeber, Bernard ; Feihl, François ; Rosenblatt-Velin, Nathalie

In: Basic Research in Cardiology, 2015, vol. 110, no. 1, p. 1-17

A dual epimorphic and compensatory mode of heart regeneration in zebrafish

Sallin, Pauline ; Preux Charles, Anne-Sophie de ; Duruz, Vincent ; Pfefferli, Catherine ; Jaźwińska, Anna

In: Developmental Biology, 2015, vol. 399, no. 1, p. 27–40

Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodetection of phosphohistone H3 and embryonic ventricular heavy chain myosin highlighted two distinct...

The regenerative capacity of the zebrafish heart is dependent on TGFβ signaling

Chablais, Fabian ; Jaźwińska, Anna

In: Development, 2012, vol. 139, p. 1921-1930

Mammals respond to a myocardial infarction by irreversible scar formation. By contrast, zebrafish are able to resolve the scar and to regenerate functional cardiac muscle. It is not known how opposing cellular responses of fibrosis and new myocardium formation are spatially and temporally coordinated during heart regeneration in zebrafish. Here, we report that the balance between the reparative...