In: Mycotoxin Research, 2015, vol. 31, no. 3, p. 151-164
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In: Diabetologia, 2015, vol. 58, no. 8, p. 1827-1835
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In: Clinical Oral Investigations, 2015, vol. 19, no. 2, p. 385-399
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In: Nature communications, 2015, vol. 6, p. 7375
Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. In this study, we characterize 21 GM-CSF autoantibodies from PAP patients and find that somatic mutations critically determine their specificity for the self-antigen. Individual antibodies only partially neutralize GM-CSF...
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In: Journal of Molecular Medicine, 2014, vol. 92, no. 7, p. 757-767
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In: Proceedings of the national academy of sciences of the United States of America, 2017, vol. 114, no. 14, p. E2891-E2900
Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses toward environmental allergens and protecting against allergic diseases. Still, the precise molecular cues that underlie their transcriptional and functional specification remain elusive. Here, we show that the cytokine activin-A instructs the generation of CD4+ T cells that express the...
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In: Chimia : International journal for chemistry, 2016, vol. 70, no. 12, p. 856-859
The in vitro synthesis of correctly folded functional proteins remains challenging. Chemokines, which consist of only 70–100 amino acids, are accessible through solid- phase synthesis and easily fold into a thermally stable tertiary structure. From the time of their discovery in the late 1980s chemokines could therefore be synthesized using biochemical and chemical protocols for...
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In: Pediatric Surgery International, 2012, vol. 28, no. 5, p. 507-513
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In: Experimental Brain Research, 2006, vol. 173, no. 2, p. 243-257
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In: Seminars in Immunopathology, 2007, vol. 29, no. 2, p. 151-162
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