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COX-2 mRNA Expression is Significantly Increased in Acid-exposed Compared to Nonexposed Squamous Epithelium in Gastroesophageal Reflux Disease

Lurje, Georg ; Vallbohmer, Daniel ; Collet, Peter ; Xi, Huan ; Baldus, Stephan ; Brabender, Jan ; Metzger, Ralf ; Heitmann, Michaela ; Neiss, Susanne ; Drebber, Ute ; Holscher, Arnulf ; Schneider, Paul

In: Journal of Gastrointestinal Surgery, 2007, vol. 11, no. 9, p. 1105-1111

May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma?

Opitz, Isabelle

In: European Journal of Cardio-Thoracic Surgery, 2010, vol. 38, no. 3, p. 252-253

Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells

Zaric, J. ; Joseph, J.-M. ; Tercier, S. ; Sengstag, T. ; Ponsonnet, L. ; Delorenzi, M. ; Rüegg, Curzio

In: Oncogene, 2012, vol. 31, p. 48-59

Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors (COXIBs) reduces the risk of cancer development and progression, in particular of the colon. The COXIB...