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PECAM-1 stabilizes blood-brain barrier integrity and favors paracellular T-Cell diapedesis across the blood-brain barrier during neuroinflammation

Wimmer, Isabella ; Tietz, Silvia ; Nishihara, Hideaki ; Deutsch, Urban ; Sallusto, Federica ; Gosselet, Fabien ; Lyck, Ruth ; Muller, William A. ; Lassmann, Hans ; Engelhardt, Britta

In: Frontiers in immunology, 2019, vol. 10, p. 711

Breakdown of the blood-brain barrier (BBB) and increased immune cell trafficking into the central nervous system (CNS) are hallmarks of the pathogenesis of multiple sclerosis (MS). Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is expressed on cells of the vascular compartment and regulates vascular integrity and immune cell trafficking. Involvement of PECAM-1 in MS pathogenesis...

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

Steiner, Esther ; Enzmann, Gaby ; Lyck, Ruth ; Lin, Shuo ; Rüegg, Markus ; Kröger, Stephan ; Engelhardt, Britta

In: Cell and Tissue Research, 2014, vol. 358, no. 2, p. 465-479

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

Pfeiffer, Friederike ; Schäfer, Julia ; Lyck, Ruth ; Makrides, Victoria ; Brunner, Sarah ; Schaeren-Wiemers, Nicole ; Deutsch, Urban ; Engelhardt, Britta

In: Acta Neuropathologica, 2011, vol. 122, no. 5, p. 601-614

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction

Engelhardt, Britta ; Sorokin, Lydia

In: Seminars in Immunopathology, 2009, vol. 31, no. 4, p. 497-511

Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts

Hamm, Stefan ; Dehouck, Bénédicte ; Kraus, Jörg ; Wolburg-Buchholz, Karen ; Wolburg, Hartwig ; Risau, Werner ; Cecchelli, Roméo ; Engelhardt, Britta ; Dehouck, Marie-Pierre

In: Cell and Tissue Research, 2004, vol. 315, no. 2, p. 157-166

Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions

Török, Michael ; Huwyler, Jörg ; Gutmann, Heike ; Fricker, Gert ; Drewe, Jürgen

In: Experimental Brain Research, 2003, vol. 153, no. 3, p. 356-365

Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue

Haenggi, T. ; Fritschy, J.

In: Cellular and Molecular Life Sciences CMLS, 2006, vol. 63, no. 14, p. 1614-1631