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Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression

Reiner, Martin F. ; Akhmedov, Alexander ; Stivala, Simona ; Keller, Stephan ; Gaul, Daniel S. ; Bonetti, Nicole R. ; Savarese, Gianluigi ; Glanzmann, Martina ; Zhu, Cuicui ; Ruf, Wolfram ; Yang, Zhihong ; Matter, Christian M. ; Lüscher, Thomas F. ; Camici, Giovanni G. ; Beer, Juerg H.

In: Cardiovascular Research, 2017, vol. 113, no. 1, p. 61–69

The P2Y12 antagonist ticagrelor reduces mortality in patients with acute coronary syndrome (ACS), compared with clopidogrel, and the mechanisms underlying this effect are not clearly understood. Arterial thrombosis is the key event in ACS; however, direct vascular effects of either ticagrelor or clopidogrel with focus on arterial thrombosis and its key trigger tissue factor have not been...