In: Developmental Biology, 2007, vol. 206, no. 2, p. 469-479
The fate of the vulval cells in Caenorhabditis elegans is specified, at least in part, through a highly conserved RTK/Ras mediated signaling cascade that negatively regulates the activity of the ETS-like transcription factor LIN-1. The Hox gene lin-39 functions downstream of both, the LIN-3/RTK/Ras pathway and LIN-1 and plays a pivotal role in controlling vulva cell competence and...
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Thèse de doctorat : Université de Fribourg, 2006 ; no. 1532.
Chromatin-remodeling multiprotein complexes are critically involved in processes that include transcription, replication, chromatin assembly, and chromosome condensation. Furthermore, multiple human diseases, including Alzheimer's disease and several types of cancer, are caused by mutations in chromatin-remodeling complexes. One of these complexes is the NuRD complex (nucleosome remodelling and...
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In: Developmental Biology, 2007, vol. 302, no. 2, p. 661–669
The Notch signaling pathway controls growth, differentiation and patterning in divergent animal phyla; in humans, defective Notch signaling has been implicated in cancer, stroke and neurodegenerative disorders. Despite its developmental and medical significance, little is known about the factors that render cells to become competent for Notch signaling. Here we show that during vulval development...
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In: Nature, 2003, vol. 426, p. 620
The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between...
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