In: Human Molecular Genetics, 2014, vol. 23, no. 25, p. 6961-6972
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In: Nature Structural & Molecular Biology, 2017, vol. 24, no. 1, p. 15-22
Circadian clocks are cell-autonomous oscillators regulating daily rhythms in a wide range of physiological, metabolic and behavioral processes. Feedback of metabolic signals, such as redox state, NAD+/NADH and AMP/ADP ratios, or heme, modulate circadian rhythms and thereby optimize energy utilization across the 24-h cycle. We show that rhythmic heme degradation, which generates the signaling...
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