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Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum

Hodge, Christine A. ; Choudhary, Vineet ; Wolyniak, Michael J. ; Scarcelli, John J. ; Schneiter, Roger ; Cole, Charles N.

In: Journal of Cell Science, 2010, vol. 123, p. 141-151

Cells of Saccharomyces cerevisiae lacking Apq12, a nuclear envelope (NE)-endoplasmic reticulum (ER) integral membrane protein, are defective in assembly of nuclear pore complexes (NPCs), possibly because of defects in regulating membrane fluidity. We identified BRR6, which encodes an essential integral membrane protein of the NE-ER, as a dosage suppressor of apq12δ. Cells...