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The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Walter, Susanne ; Jumpertz, Thorsten ; Hüttenrauch, Melanie ; Ogorek, Isabella ; Gerber, Hermeto ; Storck, Steffen E. ; Zampar, Silvia ; Dimitrov, Mitko ; Lehmann, Sandra ; Lepka, Klaudia ; Berndt, Carsten ; Wiltfang, Jens ; Becker-Pauly, Christoph ; Beher, Dirk ; Pietrzik, Claus U. ; Fraering, Patrick C. ; Wirths, Oliver

In: Acta Neuropathologica, 2019, vol. 137, no. 2, p. 239–257

Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer’s disease (AD). Full-length Aβ peptides (mainly Aβ1–40 and Aβ1–42) are produced through sequential proteolytic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, studies of autopsy brain samples from AD patients have demonstrated that a...

Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

Vos, Stephanie J. B. ; Verhey, Frans ; Frölich, Lutz ; Kornhuber, Johannes ; Wiltfang, Jens ; Maier, Wolfgang ; Peters, Oliver ; Rüther, Eckart ; Nobili, Flavio ; Morbelli, Silvia ; Frisoni, Giovanni B. ; Drzezga, Alexander ; Didic, Mira ; van Berckel, Bart N. M. ; Simmons, Andrew ; Soininen, Hilkka ; Kłoszewska, Iwona ; Mecocci, Patrizia ; Tsolaki, Magda ; Vellas, Bruno ; Lovestone, Simon ; Muscio, Cristina ; Herukka, Sanna-Kaisa ; Salmon, Eric ; Bastin, Christine ; Wallin, Anders ; Nordlund, Arto ; de Mendonça, Alexandre ; Silva, Dina ; Santana, Isabel ; Lemos, Raquel ; Engelborghs, Sebastiaan ; Van der Mussele, Stefan ; Freund-Levi, Yvonne ; Wallin, Åsa K. ; Hampel, Harald ; van der Flier, Wiesje ; Scheltens, Philip ; Visser, Pieter Jelle

In: Brain, 2015, vol. 138, no. 5, p. 1327-1338

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease

Ramirez, Alfredo ; van der Flier, Wiesje M. ; Herold, Christine ; Ramonet, David ; Heilmann, Stefanie ; Lewczuk, Piotr ; Popp, Julius ; Lacour, André ; Drichel, Dmitriy ; Louwersheimer, Eva ; Kummer, Markus P. ; Cruchaga, Carlos ; Hoffmann, Per ; Teunissen, Charlotte ; Holstege, Henne ; Kornhuber, Johannes ; Peters, Oliver ; Naj, Adam C. ; Chouraki, Vincent ; Bellenguez, Céline ; Gerrish, Amy ; Heun, Reiner ; Frölich, Lutz ; Hüll, Michael ; Buscemi, Lara ; Herms, Stefan ; Kölsch, Heike ; Scheltens, Philip ; Breteler, Monique M. ; Rüther, Eckart ; Wiltfang, Jens ; Goate, Alison ; Jessen, Frank ; Maier, Wolfgang ; Heneka, Michael T. ; Becker, Tim ; Nöthen, Markus M.

In: Human Molecular Genetics, 2014, vol. 23, no. 24, p. 6644-6658