Ergebnisse einschränken

Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome

Hiebert, Paul ; Wietecha, Mateusz S. ; Cangkrama, Michael ; Haertel, Eric ; Mavrogonatou, Eleni ; Stumpe, Michael ; Steenbock, Heiko ; Grossi, Serena ; Beer, Hans-Dietmar ; Angel, Peter ; Brinckmann, Jürgen ; Kletsas, Dimitris ; Dengjel, Jörn ; Werner, Sabine

In: Developmental Cell, 2018, vol. 46, no. 2, p. 145-161.e10

Nrf2 is a key regulator of the antioxidant defense system, and pharmacological Nrf2 activation is a promising strategy for cancer prevention and promotion of tissue repair. Here we show, however, that activation of Nrf2 in fibroblasts induces cellular senescence. Using a combination of transcriptomics, matrix proteomics, chromatin immunoprecipitation and bioinformatics we demonstrate that...