Perfeziona i miei risultati

Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit

Widmer, Yves F. ; Fritsch, Cornelia ; Jungo, Magali M. ; Almeida, Silvia ; Egger, Boris ; Sprecher, Simon G.

In: eLife, 2018, vol. 7, p. e39196

Lasting changes in gene expression are critical for the formation of long-term memories (LTMs), depending on the conserved CrebB transcriptional activator. While requirement of distinct neurons in defined circuits for different learning and memory phases have been studied in detail, only little is known regarding the gene regulatory changes that occur within these neurons. We here use the...

Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster

Widmer, Yves F. ; Bilican, Adem ; Bruggmann, Rémy ; Sprecher, Simon G.

In: Genetics, 2018, vol. 209, no. 4, p. 1167–1181

Memory formation is achieved by genetically tightly controlled molecular pathways that result in a change of synaptic strength and synapse organization. While for short- term memory traces, rapidly acting biochemical pathways are in place, the formation of long-lasting memories requires changes in the transcriptional program of a cell. Although many genes involved in learning and memory...

Mushroom body-specific profiling of gene expression identifies regulators of long-term memory in Drosophila

Widmer, Yves F. ; Bilican, Adem ; Bruggmann, Rémy ; Sprecher, Simon G.

Memory formation is achieved by genetically tightly controlled molecular pathways that result in a change of synaptic strength and synapse organization. While for short- term memory traces rapidly acting biochemical pathways are in place, the formation of long-lasting memories requires changes in the transcriptional program of a cell. Although many genes involved in learning and memory...