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Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Orlando, Ilaria M. C. ; Lafleur, Véronique N. ; Storti, Federica ; Spielmann, Patrick ; Crowther, Lisa ; Santambrogio, Sara ; Schödel, Johannes ; Hoogewijs, David ; Mole, David R. ; Wenger, Roland H.

In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...

Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1α-deficient mouse embryonic fibroblasts

Wirthner, Renato ; Wrann, Simon ; Balamurugan, Kuppusamy ; Wenger, Roland H. ; Stiehl, Daniel P.

In: Carcinogenesis, 2008, vol. 29, no. 12, p. 2306-2316

A Polyoma-Based Episomal Vector Efficiently Expresses Exogenous Genes in Mouse Embryonic Stem Cells

Camenisch, Gieri ; Gruber, Markus ; Donoho, Greg ; Van Sloun, Petra ; Wenger, Roland H. ; Gassmann, Max

In: Nucleic Acids Research, 1996, vol. 24, no. 19, p. 3707-3713

Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling

Wollenick, Kristin ; Hu, Jun ; Kristiansen, Glen ; Schraml, Peter ; Rehrauer, Hubert ; Berchner-Pfannschmidt, Utta ; Fandrey, Joachim ; Wenger, Roland H. ; Stiehl, Daniel P.

In: Nucleic Acids Research, 2012, vol. 40, no. 5, p. 1928-1943

HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia

Wrann, Simon ; Kaufmann, Muriel R. ; Wirthner, Renato ; Stiehl, Daniel P. ; Wenger, Roland H.

In: Biological Chemistry, 2013, vol. 394, no. 4, p. 519-528

Autologous stem cell transplantation: leukapheresis product has anti-angiogenic effects in vivo correlating with neutrophil-derived VEGFR1

Luethy, Anita ; Stenner, Frank ; Lohri, Corinne ; Muller, Christoph ; Samaras, Panagiotis ; Steiner, Rudolf ; Broek, Maries Van Den ; Mischo, Axel ; Renner, Christoph ; Knuth, Alexander ; Rüegg, Curzio ; Wenger, Roland H. ; Zweifel, Martin

In: Anticancer Research, 2011, vol. 31, no. 10, p. 3115-3124

Background: High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) is used for the treatment of hemato-oncologic malignancies. In this study, we measured the effect of HDC/ASCT on plasma concentrations of antiangiogenic soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and of leukapheresis products (LP) and patient serum on chick chorioallantoic...