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Hypoxia pathway proteins are master regulators of erythropoiesis

Watts, Deepika ; Gaete, Diana ; Rodriguez, Diego ; Hoogewijs, David ; Rauner, Martina ; Sormendi, Sundary ; Wielockx, Ben

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8131

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO- producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia);...