Université de Fribourg

A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system

Schmidlin, Eric ; Jouffrais, Christophe ; Freund, Patrick ; Wannier-Morino, Patrizia ; Beaud, Marie-Laure ; Rouiller, Eric M. ; Wannier, Thierry

In: BMC Neuroscience, 2009, vol. 10, p. 155

Background Polymicrogyria is a malformation of the cerebral cortex often resulting in epilepsy or mental retardation. It remains unclear whether this pathology affects the structure and function of the corticospinal (CS) system. The anatomy and histology of the brain of one macaque monkey exhibiting a spontaneous polymicrogyria (PMG monkey) were examined and compared to the brain of normal...

Université de Fribourg

Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: Effects of an antibody treatment neutralizing Nogo-A

Wannier-Morino, Patrizia ; Schmidlin, Eric ; Freund, Patrick ; Belhaj-Saif, Abderraouf ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M. ; Wannier, Tierry

In: Brain Research, 2008, vol. 1217, p. 96-109

The present study describes in primates the effects of a spinal cord injury on the number and size of the neurons in the magnocellular part of the red nucleus (RNm), the origin of the rubrospinal tract, and evaluates whether a neutralization of Nogo-A reduces the lesioned-induced degenerative processes observed in RNm. Two groups of monkeys were subjected to unilateral section of the spinal cord...